분자유전학실험실 (단국대학교 분자생물학과)



 이성욱 ( 2017-09-15 23:07:03 , Hit : 659
 DNA Construction

The Scientist »
Multimedia »
Infographics

http://www.the-scientist.com/?articles.view/articleNo/49890/title/DNA-Construction/&utm_campaign=NEWSLETTER_TS_The-Scientist-Daily_2016&utm_source=hs_email&utm_medium=email&utm_content=56353727&_hsenc=p2ANqtz--kUaItxdAbY8PU8Lk0f2PwSy-qWWun9q8STnPqqB3ToG40hX_NsLkuXKdkUqOdeSNgRCMT7PE9aSCi5_aiZ13b-_uX6g&_hsmi=56353727


Researchers have devised multiple ways to build nanoscale structures from the nucleic acid.

By Arun Richard Chandrasekaran | July 17, 2017



AddThis Sharing Buttons
Share to FacebookShare to TwitterShare to RedditShare to 이메일Share to 더 보기



DNA AS BRICKS AND MORTAR

The straightforward and consistent pairing of DNA’s nucleotide bases make the molecule a reliable building material. Depending on the sequence, DNA strands can crossover to adjacent helices, creating a branch point. Researchers can develop such connecting pieces, called branched DNA junctions, with 4, 5, 6, 8, or 12 arms, projecting from a central hub at various angles in three-dimensional space.

DNA CROSSOVER







© ISTOCK.COM/SHUOSHU

BRANCHED DNA JUNCTIONS


© ISTOCK.COM/SHUOSHU

STRUCTURAL GLUE
The ends of the molecules can be designed to contain single-stranded “sticky ends” that enable researchers to encode the predictable selfassembly of larger nanostructures.
  


© ISTOCK.COM/MUSTAFAHACALAKI

DNA SELF ASSEMBLY


© ISTOCK.COM/MUSTAFAHACALAKI



DNA ORIGAMI

By folding a long, single-stranded DNA scaffold using short, single-stranded “staples,” researchers can build any shape they like. For example, researchers recently designed a three-dimensional bunny, using computer algorithms to determine the folding pathways and DNA sequences that would be required to create the desired shape.


ARUN RICHARD CHANDRASEKARAN

ERIK BENSON & BJÖRN HÖGBERG. ATTRIBUTION 4.0 INTERNATIONAL (CC BY 4.0)

MULTIDIMENSIONAL DNA ARRAYS

Researchers can also design small DNA motifs that self-assemble into lattices. Shown below is a “tensegrity triangle” motif with three double helical edges (represented as cylinders) that contain complementary sticky ends along one, two, or all three of its edges, leading to assembly of one-, two-, or three-dimensional arrays.


DIAGRAM: ARUN RICHARD CHANDRASEKARAN; © ISTOCK.COM/SHUOSHU







1047   CRISPR/Cas9 Edits Epigenome with Therapeutic Efficiency  이성욱 2017/12/09 484
1046   [바이오토픽] 체크포인트 저해제의 부작용: 자가면역질환 초래  이성욱 2017/11/16 686
1045   DNA Repair Mechanism Aids Cancer by Mending Chemo Damage  이성욱 2017/11/10 567
1044   FDA Approves Gilead CAR-T Therapy Yescarta, Plans Regenerative Medicine Policy 'Soon'  이성욱 2017/10/20 607
1043   Advisors to FDA Recommend Approval of Gene Therapy for Blindness  이성욱 2017/10/14 665
1042   CRISPR System Targets RNA in Mammalian Cells  이성욱 2017/10/06 640
1041   Nonviral CRISPR Delivery a Success  이성욱 2017/10/03 555
1040   Giants of Circadian Biology Win Nobel Prize  이성욱 2017/10/03 499
1039   To Speed CRISPR/Cas9’s Search and Snip, Try Extra Cas9 and gRNA  이성욱 2017/09/30 1989
1038   Technique Adapted from CRISPR-Cas9 Corrects Mutation in Human Embryos  이성욱 2017/09/29 505
1037   Mutations Making CRISPR Hyper-Accurate Discovered  이성욱 2017/09/22 852
1036   CRISPR Used in Human Embryos to Probe Gene Function  이성욱 2017/09/22 582
1035   Alcoholism Gene Therapy Shows Promise  이성욱 2017/09/20 582
  DNA Construction  이성욱 2017/09/15 659
1033   Cargo-Sorting DNA Robots  이성욱 2017/09/15 1138
1032   From Startups to Moguls] CRISPR 유전자가위 없이 편집한다? Homology Medicines  이성욱 2017/09/11 603
1031   Outsourcing Gene Editing to the Public-Online Game Challenges Players to Design CRISPR On/Off Switch  이성욱 2017/09/05 722
1030   Scientists Doubt Results of CRISPR’d Embryos  이성욱 2017/09/02 539
1029   Scientists Look to Epigenetics to Thwart Viruses  이성욱 2017/09/02 709
1028   First CAR T-Cell Therapy Approved in U.S.  이성욱 2017/09/01 689

[이전 10개] [1]..[11] 12 [13][14][15][16][17][18][19][20]..[64] [다음 10개]
 

Copyright 1999-2021 Zeroboard / skin by ROBIN