분자유전학실험실 (단국대학교 분자생물학과)



 이성욱 ( 2011-01-11 10:34:23 , Hit : 2566
 Parallels Between Cancers, Infection Suppression: Same Proteins Involved, but Cancer Takes Hold When Response Gets out of Control

ScienceDaily (Jan. 4, 2011) — Tiny parasitoid wasps can play an important role in controlling the populations of other insect species by laying their eggs inside the larvae of these species. A newly hatched wasp gradually eats the host alive and takes over its body.

The host insect is far from defenseless, however. In Drosophila (fruit flies), larvae activate humoral immunity in the fat body and mount a robust cellular response that encapsulates and chokes off the wasp egg.

New research by Dr. Shubha Govind, professor of biology at The City College of New York, and colleagues reveals parallels between how this mechanism fights the wasp infection and the way blood cancer develops. "There are fundamental similarities in the processes," she explains. "The response to wasp infection is similar to acute inflammation while the cancer is akin to chronic inflammation in mammals, where regulation of the response to an infection also goes out of control."

Professor Govind reports that the immune system that counters wasp egg infection is highly restrained. The system works like a thermostat, with certain proteins detecting the infection and triggering the immune reactions. Once the egg has been destroyed the immune reactions come to a halt.

However, when the regulating mechanism goes haywire, cancer can develop. Through sumoylation, the correct balance between positive and negative factors is achieved, Professor Govind and colleagues report.

"There is strong evidence that the fundamental mechanism of regulation uncovered in flies also works in humans," she notes. "Because of the molecular similarities between flies and mammals, it may be possible to use flies to test drugs for potential anti-inflammatory effects in human disease." While such drugs would not cure cancer, they could control inflammation and, perhaps, delay cancer progression.

Other potential applications are in pest control for agriculture. Instead of using insecticides, parasitoids with the ability to suppress the hosts' immune systems could be used to kill insect pests. Also, insecticides could be developed that, at very low concentrations, would weaken the immune systems of host insects and enable parasitoid eggs to succeed, Professor Govind adds.

The findings were published last month in PLoS Pathogens, a peer-reviewed, open-access journal published by the Public Library of Science. Contributing scientists were: Indira Paddibhatla, Mark J. Lee, Marta E. Kalamarz and Roberto Ferrarese. The work was funded by the National Institutes of General Medicine, U.S. Department of Agriculture and PSC-CUNY.

Email or share this story:| More
--------------------------------------------------------------------------------

Story Source:

The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by City College of New York.

--------------------------------------------------------------------------------

Journal Reference:

David S. Schneider, Indira Paddibhatla, Mark J. Lee, Marta E. Kalamarz, Roberto Ferrarese, Shubha Govind. Role for Sumoylation in Systemic Inflammation and Immune Homeostasis in Drosophila Larvae. PLoS Pathogens, 2010; 6 (12): e1001234 DOI: 10.1371/journal.ppat.1001234







967   Strides Against Hepatitis C Open Door to Blockbusters  이성욱 2010/11/02 2520
966   Black patients fare well on Vertex hepatitis C drug  이성욱 2010/11/02 2656
965   NC State Develops More Precise Genetic ‘Off Switches’  이성욱 2010/11/03 2592
964   Breakthrough in cancer vaccine research  이성욱 2010/11/08 2633
963   DNA sequence may be lost in translation  이성욱 2010/11/10 2738
962   Lung Cancer in Smokers, Nonsmokers May Be a Different Disease  이성욱 2010/11/10 2539
961   Why brain tumors hard to treat  이성욱 2010/11/23 2879
960   Vertex submits application for hepatitis C drug  이성욱 2010/11/25 3386
959   Tumours grow their own blood vessels  이성욱 2010/11/25 2308
958   Top 5 papers of 2010  이성욱 2010/12/10 2289
957   Microbe gets toxic response  이성욱 2010/12/10 2424
956   Basel Declaration defends animal research  이성욱 2010/12/10 2316
955   Missing Molecules Hold Promise of Therapy for Pancreatic Cancer: Lost microRNAs Put Brakes on Tumors  이성욱 2010/12/22 2210
954   HIV patient with leukemia treated through stem cell transplant  이성욱 2010/12/23 4967
953   Top 5 papers of 2010  이성욱 2010/12/28 2550
952   Smoking May Worsen Pain For Cancer Patients  이성욱 2010/12/28 2655
951   key interaction in hepatitis C virus  이성욱 2010/12/30 2207
  Parallels Between Cancers, Infection Suppression: Same Proteins Involved, but Cancer Takes Hold When Response Gets out of Control  이성욱 2011/01/11 2566
949   Cancer Can Develop in Catastrophic Burst  이성욱 2011/01/13 2809
948   Viral Evasion Gene Reveals New Targets for Eliminating Chronic Infections  이성욱 2011/01/17 2299

[이전 10개] [1]..[11][12][13][14][15] 16 [17][18][19][20]..[64] [다음 10개]
 

Copyright 1999-2021 Zeroboard / skin by ROBIN