분자유전학실험실 (단국대학교 분자생물학과)



 이성욱 ( 2011-09-17 13:02:39 , Hit : 2387
 Can a Form of HIV Actually Cure Cancer?

stunning new therapy could be a significant leap forward in treating Leukemia and other cancers.
By Greg Howard | Posted Tuesday, Sep. 13, 2011, at 2:13 PM EDT

University of Pennsylvania doctors have used gene therapy to train a patient’s own immune system to kill leukemia cells.

The New York Times reports that doctors gutted and reconstructed a disabled form of HIV-1 by selecting DNA from humans, mice and cows, a virus that infects woodchucks, and one that infects cows. The virus infects T-cells, a white blood cell that fights viruses and tumors, and alters the T-cells to reproduce chimeric antigen receptors, or CARS – protein complexes that transform the cells into “serial killers.” The T-cells recognize cancer, attack it, multiply, and continue to live on after the eradication of the cancer, patrolling the body to defend against relapses.

Doctors first tried the experimental treatment on William Ludwig, then a 65-year-old retired corrections officer from Bridgeton, NJ. Researchers passed Ludwig’s blood through a machine that removed about a billion T-cells before returning the blood back into his veins. The removed T-cells were introduced to the HIV virus, which infected and genetically transformed Ludwig’s T-cells, and then temporarily frozen. After chemotherapy to deplete any remaining T-cells that may have impeded the growth of the altered ones, the new T-cells were infused back into Ludwig’s blood.

Dr. Carl June, head of the research team, explains that, “The patient then becomes a bioreactor.” After 10 days, as the T-cells reproduced, Ludwig began shaking with chills, his temperature spiked, and his blood pressure dropped dangerously. The T-cells were producing chemicals called cytokines that caused flulike symptoms.

After a few weeks, the symptoms were gone, and with them, the leukemia. Ludwig’s doctors estimated that the treatment had killed two pounds of cancer cells in his blood.

Ludwig’s doctors cannot say that he is cured, as it has only been a year since the operation, but even Dr. June admits that he and his colleagues were stunned by the results. Although reconstructed HIV has been used to treat other diseases, never before has it been used to treat cancer.

Ludwig says that he feels wonderful, and is even walking through all 18 holes of golf. “I have my life back,” he says.

Since Ludwig, two other patients have been treated. One experienced full remission. When the other developed chills and fever, another hospital treated him with steroids, and may have disrupted the T-cells’ activity.  Doctors also noted that his leukemia may have been too advanced. Still, he experienced partial remission.

Experts in the field said that the results signified a giant leap in molecular biology. Other cancers may also be vulnerable to the new treatment. Dr. June plans on next testing his team’s treatment against solid tumors, including hard-to-treat cancers like mesothelioma and ovarian and pancreatic cancer.








867   Turning T-cells into Cancer Killers  이성욱 2011/08/12 2557
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859   Gene Therapy for Immune Disorder Lasts Nine Years, Two New Studies Show  이성욱 2011/08/25 2505
858   An RNA Switch for Stem Cells  이성욱 2011/08/31 2463
857   Engineered Viruses Selectively Kill Cancer Cells  이성욱 2011/09/02 2471
856   Genetic circuit kills cancer cells using unique microRNAs  이성욱 2011/09/08 4970
855   Researchers Successfully Perform First Injection of Cultured Red Blood Cells in Human Donor  이성욱 2011/09/08 2377
854   Breast-cancer gene keeps DNA under wraps  이성욱 2011/09/10 2297
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852   Obscure Organelle in Stem Cells and Cancer  이성욱 2011/09/13 2397
851   UK Duo Generates Haploid Mouse Stem Cells  이성욱 2011/09/14 2438
  Can a Form of HIV Actually Cure Cancer?  이성욱 2011/09/17 2387
849   Mammoth blood proteins could be used in major surgery  이성욱 2011/09/20 3175
848   Ribosomes in Control  이성욱 2011/09/20 2650

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