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 이성욱 ( 2017-09-15 23:07:03 , Hit : 655
 DNA Construction

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http://www.the-scientist.com/?articles.view/articleNo/49890/title/DNA-Construction/&utm_campaign=NEWSLETTER_TS_The-Scientist-Daily_2016&utm_source=hs_email&utm_medium=email&utm_content=56353727&_hsenc=p2ANqtz--kUaItxdAbY8PU8Lk0f2PwSy-qWWun9q8STnPqqB3ToG40hX_NsLkuXKdkUqOdeSNgRCMT7PE9aSCi5_aiZ13b-_uX6g&_hsmi=56353727


Researchers have devised multiple ways to build nanoscale structures from the nucleic acid.

By Arun Richard Chandrasekaran | July 17, 2017



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DNA AS BRICKS AND MORTAR

The straightforward and consistent pairing of DNA’s nucleotide bases make the molecule a reliable building material. Depending on the sequence, DNA strands can crossover to adjacent helices, creating a branch point. Researchers can develop such connecting pieces, called branched DNA junctions, with 4, 5, 6, 8, or 12 arms, projecting from a central hub at various angles in three-dimensional space.

DNA CROSSOVER







© ISTOCK.COM/SHUOSHU

BRANCHED DNA JUNCTIONS


© ISTOCK.COM/SHUOSHU

STRUCTURAL GLUE
The ends of the molecules can be designed to contain single-stranded “sticky ends” that enable researchers to encode the predictable selfassembly of larger nanostructures.
  


© ISTOCK.COM/MUSTAFAHACALAKI

DNA SELF ASSEMBLY


© ISTOCK.COM/MUSTAFAHACALAKI



DNA ORIGAMI

By folding a long, single-stranded DNA scaffold using short, single-stranded “staples,” researchers can build any shape they like. For example, researchers recently designed a three-dimensional bunny, using computer algorithms to determine the folding pathways and DNA sequences that would be required to create the desired shape.


ARUN RICHARD CHANDRASEKARAN

ERIK BENSON & BJÖRN HÖGBERG. ATTRIBUTION 4.0 INTERNATIONAL (CC BY 4.0)

MULTIDIMENSIONAL DNA ARRAYS

Researchers can also design small DNA motifs that self-assemble into lattices. Shown below is a “tensegrity triangle” motif with three double helical edges (represented as cylinders) that contain complementary sticky ends along one, two, or all three of its edges, leading to assembly of one-, two-, or three-dimensional arrays.


DIAGRAM: ARUN RICHARD CHANDRASEKARAN; © ISTOCK.COM/SHUOSHU







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