분자유전학실험실 (단국대학교 분자생물학과)



 이성욱 ( 2015-01-07 01:00:59 , Hit : 1302
 CVS Gives Preferred Status to Gilead’s Hepatitis C Drugs

AbbVie’s Viekira Pak Will be Available If a Patient Receives Medical Exception or Prior Authorization


AbbVie’s Viekira Pak isn’t included on CVS Health’s drug formulary.  Bloomberg News  
.

By
Joseph Walker









Updated Jan. 5, 2015 12:27 p.m. ET  


The battle for supremacy in one of the fastest-growing pharmaceutical markets intensified on Monday, with  CVS Health  Corp. saying it will make  Gilead Sciences  Inc. ’s drugs Sovaldi and Harvoni the exclusive options for patients with hepatitis C.

A competing treatment made by  AbbVie  Inc., called Viekira Pak, will be excluded from CVS’s drug formulary of approved medications, except in cases when it is medically necessary, CVS said in a letter sent to employment-benefit consultants that was reviewed by The Wall Street Journal.

The letter from CVS, a retail chain and pharmacy-benefits manager, doesn’t indicate whether Gilead gave CVS a discount on the expensive hepatitis C drugs. Sovaldi costs $84,000 per patient and Harvoni $94,500 per patient in the U.S. for 12-week treatments. Gilead and CVS declined to comment on specifics of the deal.

“Our goal was to create the lowest net-cost solution for the entire population of patients with all genotypes of hepatitis C,” Christine K. Cramer, a CVS spokeswoman, said in an email. CVS made its decision based on a clinical review of the different hepatitis C regimens and their costs, she said.




AbbVie’s Viekira Pak costs $83,319 per patient in the U.S. for a 12-week regimen.


World-wide sales of new hepatitis C drugs, which have higher cure rates and fewer side effects than older therapies for the viral liver disease, are estimated to have reached $13 billion in 2014, according to RBC Capital Markets. The hepatitis C drug market is expected to grow 42% to $18.5 billion this year, RBC said.

Doctors and patients have praised the drugs’ cure rates, but insurers and state health officials have criticized their pricing, calling it unsustainable. Many state Medicaid programs have limited access to the drugs because of the cost.

Express Scripts Holding  Co. , the largest U.S. pharmacy benefit manager, said in December it had agreed to give preferred formulary status to AbbVie’s Viekira Pak in exchange for a discount from AbbVie. Express Scripts, which has been among the most vocal critics of Gilead’s pricing of hepatitis C drugs, said it would exclude from its formularies Gilead’s drugs for hepatitis C patients with the most common form of the disease, known as genotype 1. Express Scripts also said it would make AbbVie’s drug available to all patients, regardless of their disease severity.

Gilead shares fell 13% through the end of December after the agreement between Express Scripts and AbbVie was announced, with some investors worried AbbVie would use price discounting to gain a larger share of the hepatitis C drug market than anticipated. The Nasdaq Biotechnology Index fell 4.1% over the same period as some analysts worried of increased pressure from pharmacy-benefit managers and health insurers on drug pricing.

On Monday, shares of Gilead were up 2% to $96.79. AbbVie shares fell 1.9% to $64.65.



Further reading

Docs Divided Over Discount on AbbVie Drug
The Hepatitis C Price Wars Begin
AbbVie Pins Hopes on Hepatitis C Treatment
.
CVS’s policy will go into effect Jan. 7 and will apply to all hepatitis C genotypes. The company’s policy will apply to Medicare and Medicaid patients who receive drug benefits through CVS, as well as beneficiaries covered under health plans sold through marketplace exchanges and CVS’s standard commercial formulary. The change won’t necessarily apply to CVS customers who use custom formularies, the CVS letter said.

Sales of Gilead’s Sovaldi, approved in late 2013, were $8.55 billion in the first three quarters of 2014 in what is thought to be the most successful drug launch ever. Harvoni was approved by the Food and Drug Administration this past October as the first treatment for genotype 1 cases of hepatitis C that doesn’t require two older drugs known to cause serious side effects.

AbbVie received approval for its Viekira Pak on Dec. 19.

“Gilead is very pleased to have reached an agreement with CVS that will enable access to Harvoni for people living with HCV,” Amy Flood, a Gilead spokeswoman, said in an email.

Viekira Pak is thought to be as effective as Gilead’s drugs in genotype 1 patients, though not as convenient because it requires patients to take more pills at one time.

“Our multiyear agreement with Express Scripts is an example of how we will ensure all hepatitis C patients beyond just the very sickest…gain access to treatment,” David Freundel, an AbbVie spokesman, said in an email.

“We welcome others to follow our lead,” Brian Henry, an Express Scripts spokesman, said of CVS’s agreement with Gilead.

—Peter Loftus contributed to this article.

Write to Joseph Walker at joseph.walker@wsj.com







1147   CRISPR/Cas9의 대안: CRISPR/Cpf1  이성욱 2015/09/29 1414
1146   CRISPR: No Cutting Required  이성욱 2016/08/06 1636
1145   CRISPR’s MAGESTIC Evolution Makes Gene Editing More Precise  이성욱 2018/05/08 414
1144   CRISPR을 이용하여 마우스의 헌팅톤병 치료 성공  이성욱 2015/10/29 1166
1143   CRISPR의 능력을 배가(倍加)시키는 미니 유전자  이성욱 2015/04/02 1151
1142   CTLA-4 항체의 항암 효과를 높이는 새로운 혼합치료  이성욱 2014/04/21 2102
1141   CU-Boulder researchers uncover new target for cancer research  이성욱 2012/11/06 2704
  CVS Gives Preferred Status to Gilead’s Hepatitis C Drugs  이성욱 2015/01/07 1302
1139   C형 간염 바이러스가 간질환을 유발시키는데 필수적인 지방산 합성효소  이성욱 2008/07/14 4845
1138   C형 간염 바이러스의 E2 외피 당단백 구조  이성욱 2013/12/06 2120
1137   C형 간염 치료에서 비용 효율성을 보인 시메프레비르(simeprevir) 기반 요법  이성욱 2014/12/11 1711
1136   C형 간염, 고지혈증약으로 감염 억제  관리자 2012/01/09 3535
1135   C형 간염에 보다 효과적인 새로운 복합제  이성욱 2015/11/24 977
1134   C형간염 동물모델을 만드는 데 필요한 단백질 발견: 오클루딘(occludin)  이성욱 2009/02/11 5475
1133   C형간염 바이러스의 감염을 차단하는 천연화합물  이성욱 2010/01/08 5234
1132   C형간염 시장 ‘폭발적 성장’ 전망  이성욱 2010/05/25 5410
1131   C형간염 진단 유전자검사 개발  이성욱 2013/03/07 2876
1130   C형간염바이러스의 복제를 돕는 인간의 유전자  이성욱 2009/03/20 5010
1129   C형간염의 자가회복에 영향을 미치는 요인  이성욱 2007/09/04 4811
1128   Daclatasvir (Daklinza) for Chronic Hepatitis C Cleared in EU  이성욱 2014/08/29 2133

[1][2][3][4][5][6] 7 [8][9][10]..[64] [다음 10개]
 

Copyright 1999-2021 Zeroboard / skin by ROBIN