논문발표실적
    국제전문학술지
    (1) Lee, S.-W., Gallardo, H., Gilboa, E., and Smith, C. (1994). Inhibition of HIV-1 in Human T-cells by a potent RRE decoy consisting of the 13 nucleotide minimal rev binding domain. Journal of Virology 68: 8254-8264.

(2) Lee, S.-W., Gallardo, H., Gasper, O., Smith, C., and Gilboa, E. (1995). Inhibition of HIV-1 in CEM cells by a potent TAR decoy. Gene Therapy 2: 377-384.

(3) Lee, S.-W., Gilboa, E., and Smith, C. (1995). Inhibition of HIV-1 with minimal Rev responsive element (RRE) decoys.. International Antiviral Reviews 3:89-91.

(4) Smith, C., Lee, S.-W., and Gilboa, E. (1995). Inhibition of HIV-1 with intracellular immunization with RNA decoys. Advanced Drug Delivery Reviews 17: 369-371.

(5) Jones, J., Lee, S.-W., and Sullenger, B. (1996). Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells. Nature Medicine 2: 643-648.

(6) Rudoll, T. Phillips, K., Lee, S.-W., Hull, S., Gasper, O., Sucgang, N., Gilboa, E., and Smith, C. (1996). High efficiency retroviral vector mediated gene transfer into human peripheral blood CD4+ T-lymphocytes. Gene Therapy 3: 695-705.

(7) Lee, S.-W., Smith, C., and Gilboa, E. (1996). Inhibition of HIV-1 with a potent trans-activation responsive element (TAR) decoy. International Antiviral News 4: 39-41.

(8) Lee, S.-W., and Sullenger, B. (1996). Isolation of a nuclease resistant decoy RNA that selectively blocks autoantibody binding to insulin receptors on human lymphocytes. Journal of Experimental Medicine 184: 315-324.

(9) Smith, C., Lee, S.-W., Wong, E., Gallardo, H., Page, K., Gasper, O., Lebkowski, J., and Gilboa, E. (1996). Transient protection of human T-cells from human immunodeficiency virus type 1 infection by transduction with adeno-associated viral vectors which express RNA decoys. Antiviral Research 32: 99-115.

(10) Jones, J., Lee, S.-W., and Sullenger, B. (1997). Trans-splicing reactions by ribozymes. Methods in Molecular Biology 74: 341-348.

(11) Lee, S.-W., and Sullenger, B. (1997). Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. Nature Biotechnology 15: 41-45. (Selected as a featured article)

(12) Lan, N., Howrey, R., Lee, S.-W., Smith, C., and Sullenger, B. (1998) Ribozyme-mediated repair of sickle β-globin mRNAs in erythrocyte precursors. Science 280: 1593-1596.

(13) Lee, S.-W., and Gilboa, E. (1998). High level accumulation of an aberrantly spliced human DHFR RNA species. Molecules and Cells 8: 189-200.

(14) Lee, S.-W. (1998). Studies on the inhibition of HIV replication with a number of RRE decoy derivatives. The Journal of Microbiology 36: 308-315.

(15) Lan, N., Rooney, B. L., Lee, S.-W., Howrey, R. P., Smith, C. A., and Sullenger, B. A. (2000) Enhancing RNA repair efficiency by combining trans-splicing ribozymes that recognize different accessible sites on a target RNA. Molecular Therapy 2: 245-255.

(16) Seo, H.-S., and Lee, S.-W. (2000) In vitro selection of the 2'-fluoro-2'-deoxyribonucleotide decoy RNA inhibitor of myasthenic autoantibodies. Journal of Microbiology and Biotechnology 10: 707-713.

(17) Jeong, S., Eom, T.-Y., Kim, S.-J., Lee. S.-W., and Yu, J. (2001) In vitro selection of the RNA aptamer against the sialyl lewis X and its inhibition of the cell adhesion. Biochemical and Biophysical Research Communications 281: 237-243.

(18) Hwang, B., and Lee, S.-W. (2002) Improvement of RNA Aptamer Activity against Myasthenic Autoantibodies by Extended Sequence Selection. Biochemical and Biophysical Research Communications 290: 656-662.

(19) Bae, S.-J., Oum, J.-H., Sharma, S., Park, J., and Lee, S.-W. (2002) In vitro selection of specific RNA inhibitors of NFATc. Biochemical and Biophysical Research Communications 298: 486-492.

(20) Shin, K.-S., Bae, S.-J., Hwang, E.-S., Jeong, S., and Lee, S.-W. (2002) Ribozyme-mediated replacement of p53 RNA by targeted trans-splicing. Journal of Microbiology and Biotechnology 12: 844-848.

(21) Han, J., Kim, M., Oum, J.-H., Myung, H., Lee, S.-W., Jeong, S., Sharma, S., and Park, J. (2002) RACK-1, a receptor for activated C kinase, interacts with the transcription factor NFAT and repressed its transactivation. Molecules and Cells 14: 420-424.

(22) Kim, H., Jeong, E., Lee, S.-W., and Han, K. (2002) Analysis of protein-RNA interactions at atomic level. Genome Informatics 13: 312-313.

(23) Ryu, K.-J., Kim, J.-H., and Lee, S.-W. (2003) Ribozyme-Mediated Selective Induction of New Gene Activity in Hepatitis C Virus Internal Ribosome Entry Site-Expressing Cells by Targeted Trans-Splicing. Molecular Therapy 7: 386-395.

(24) Hwang, B., Han, K., and Lee, S.-W. (2003) Prevention of passively transferred experimental autoimmune myasthenia gravis by an in vitro selected RNA aptamer. FEBS Letters 548: 85-89.

(25) Kim, H. Jeong, E. Lee, S.-W., and Han, K. (2003). Computational Analysis of Hydrogen Bonds in Protein-RNA Complexes for Interaction Patterns. FEBS Letters 552: 231-239.

(26) Jeong, E., Kim H., Lee, S.-W., and Han, K. (2003) Discovering interaction propensities of amino acids and nucleotides from the protein-RNA complexes. Molecules and Cells 16: 161-167.

(27) Ryu, K.-J., and Lee, S.-W. (2003) Identification of most accessible sites to ribozymes on hepatitis C virus internal ribosome entry site. Journal of Biochemistry and Molecular Biology 36: 538-544.

(28) Lee, S.-W. (2003). Improved inhibition of human immunodeficiency virus type 1 replication by intracellular co-overexpression of TAR and RRE decoys in tandem array. The Journal of Microbiology 41: 300-305.

(29) Park, Y.-H., Jung, H.-S., Kwon, B.-S., and Lee, S.-W. (2003). Replacement of thymidine phosphorylase RNA with group I intron of Tetrahymena thermophila by targeted trans-splicing. The Journal of Microbiology 41: 340-344.

(30) Hwang, B., Cho, J. S., Yeo, H. J., Kim, J.-H., Chung, K. M., Han, K., Jang, S. K., and Lee, S.-W. (2004). Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus. RNA 10: 1277-1290. (Selected as a featured article)

(31) Shin, K.-S., Sullenger, B. A., and Lee, S.-W. (2004) Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA. Molecular Therapy 10: 365-372.

(32) Cho, J.-S., Lee, Y. J., Shin, K.-S., Jeong, S., Park, J., and Lee, S.-W. (2004). In vitro selection of specific RNA aptamers for the NFAT DNA binding domain. Molecules and Cells 18: 17-23.

(33) Ryu, K.-J., and Lee, S.-W. (2004) Comparative analysis of intracellular trans-splicing ribozyme activity aganst hepatitis C virus internal ribosome entry site. The Journal of Microbiology 42: 361-364.

(34) Jung, H.-S., Kwon, B.-S., and Lee, S.-W. (2005) Tumor-specific gene delivery using RNA-targeting Tetrahymena group I intron. Biotechnology Letters 27: 567-574.

(35) Hwang, B., and Lee, S.-W. (2005). Analysis of in vivo interaction of HCV NS3 protein and specific RNA aptamer with yeast three-hybrid system. Journal of Microbiology and Biotechnology 15: 660-664.

(36) Kwon, B.-S., Jung, H.-S., Song, M.-S., Cho, K. S., Kim, S.-C.. Kimm, K., Jeong, J. S., Kim, I.-H., and Lee, S.-W. (2005). Specific Regression of Human Cancer Cells by Ribozyme-Mediated Targeted Replacement of Tumor-Specific Transcript. Molecular Therapy 12: 824-834.

(37)Jung, H.-S., and Lee, S.-W. (2005) Re-engineering of carcinoembryonic antigen RNA with the group I intron of Tetrahymena thermophila by targeted trans-splicing. Journal of Microbiology and Biotechnology 15: 1408-1413.

(38) Lee, Y. J., and Lee, S.-W. (2006) In vitro selection of cancer-specific aptamers. Journal of Microbiology and Biotechnology 16: 1149-1153.

(39)Song, M.-S., and Lee, S.-W. (2006) Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme. FEBS Letters 580: 5033-5043.

(40)Jung, H.-S., and Lee, S.-W. (2006) Ribozyme-mediated selective killing of cancer cells expressing carcinoembryonic antigen RNA by targeted trans-splicing. Biochemical and Biophysical Research Communications 349: 556-563.

(41)Shin, K.-S., Lim, J. H., Kim, J.-H., Myung, H., and Lee, S.-W. (2006) Inhibition of the replication of hepatitis C virus replicon with nuclease-resistant RNA aptamers. Journal of Microbiology and Biotechnology 16: 1634-1639.

(42)Won, Y.-S., and Lee, S.-W. (2007) Targeted retardation of hepatocarcinoma cells by specific replacement of alpha-fetoprotein RNA. Journal of Biotechnology 129: 614-619.

(43)Kim, A., Bam, G., Song, M.-S., Bae, C.-D., Park, J., and Lee, S.-W. (2007) Selective regression of cells expressing mouse cytoskeleton-associated protein 2 transcript by trans-splicing ribozyme. Oligonucleotides 17: 95-103.

(44)Jung, S., and Lee, S.-W. (2007) Expression and purification of recombinant active prostate-specific antigen from Escherichia coli. Journal of Microbiology and Biotechnology 17: 840-846.

(45)Hong, S.-H., Jeong, J.-S., Lee, Y.-J., Jung, H.-I., Kim, K. T., Kim, Y.-H., Lee, Y. S., Lee, S.-W., Bae, C.-D., Park, J., and Kim, I.-H. (2007) Molecular imaging of endogenous mRNA expression in mouse tumor model by adenovirus harboring trans-splicing ribozyme. FEBS Letters 581: 5396-5400. (Selected as a featured article and cover figure)

(46)Song, M.-S., Jeong, J.-S., Cho, K.-S., and Lee, S.-W. (2007) Gene expression responses in vivo by human telomerase reverse transcriptase (hTERT)-targeting trans-splicing ribozyme. Experimental and Molecular Medicine 39: 722-732.

(47)Hong, S.-H., Jeong, J.-S., Lee, Y.-J., Jung, H.-I., Cho, K.-S., Kim, C.-M., Kwon, B.-S., Sullenger, B. A., Lee, S.-W.*, and Kim, I.-H.* (2008) In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cell. Molecular Therapy 16: 74-80. (*; co-corresponding)

(48)Jeong, J.-S.*, Lee, S.-W.*, Hong, S.-H., Lee, Y.-J., Jung, H.-I., Cho, K.-S., Seo, H.-H., Lee, S.-J., Park, S., Song, M.-S., Kim, C.-M., and Kim, I.-H. (2008) Antitumor effects of systemically delivered adenovirus harboring trans-splicing ribozyme in intrahepatic colon cancer mouse model. Clinical Cancer Research 14: 281-290. (*; co-first)

(49)Hwang, B., Lim, J. H., Hahm, B., Jang, S. K., and Lee, S.-W. (2009) hnRNP L is required for the translation mediated by HCV IRES. Biochemical and Biophysical Research Communications 349: 556-563.

(50)Song, M.-S., Jeong, J.-S., Ban, G., Lee, J.-H., Won, Y.-S., Cho, K.-S., Kim, I.-H., and Lee, S.-W. (2009). Validation of tissue-specific promoter-driven tumor-targeting trans-splicing ribozyme system as a multifunctional cancer gene therapy device in vivo. Cancer Gene Therapy 16: 113 125. (Selected as a featured article)

(51)Ahn, D.G., Jeon, I.J., Kim, J.D., Song, M.S., Han, S.R., Lee, S.-W., Jung, H., and Oh, J.W. (2009). RNA aptamer-based sensitive detection of SARS corona virus nucleocapsid protein. Analyst 134: 1896-1901.

(52)Ban, G., Song, M.-S., and Lee, S.-W. (2009). Cancer cell targeting with mouse TERT-specific group I intron of Tetrahymena thermophila. Journal of Microbiology and Biotechnology 19: 1070-1076.

(53)Cho, J.-S., and Lee, S.-W. (2009). Sequence and structural features of RNA aptamer against myasthenic autoantibodies. Oligonucleotides 19: 273-280.

(54)Jeong, S., Han, S. R., Lee, Y. J., and Lee, S.-W. (2010). Selection of RNA aptamers specific to active prostate-specific antigen. Biotechnology Letters 32: 379-385.

(55)Lee, S. J., Lee, S.-W., Jeong, J. S., and Kim, I. H. (2010). In vivo reprogramming of human telomerase reverse transcriptase (hTERT) by trans-splicing ribozyme to target tumor cells. Methods in Molecular Biology 629: 307-321.

(56)Jeong, S., Han, S. R., Lee, Y. J., Kim, J. H., and Lee, S.-W. (2010). Identification of RNA aptamer specific to mutant KRAS protein. Oligonucleotides 20: 155-161.

(57)Chang, B., Lee, C. H., Lee, J. H., and Lee, S.-W. (2010). Comparative analysis of intracellular inhibition of hepatitis C virus replication by small interfering RNAs. Biotechnology Letters 32: 1231-1237.

(58)Hong, H.-W., Lee, S.-W., and Myung, H. (2010). Selection of peptides binding to HCV E2 and inhibiting viral infectivity. Journal of Microbiology and Biotechnology 20: 1769-1771.

(59)Kwon, B.-S., Jeong, J. S., Won, Y. S., Lee, C. H., Yoon, K.-S., Jung, M. H., Kim, I.-H., and Lee, S.-W. (2011). Intracellular efficacy of tumor-targeting group I intron-based trans-splicing ribozyme. The Journal of Gene Medicine 13: 89-100.

(60)Ban, G., Jeong, J.-S., Kim, A., Kim, S. J., Han, S.-Y., Kim, I.-H., and Lee, S.-W. (2011) Selective and efficient retardation of cancers expressing cytoskeleton-associated protein 2 by targeted RNA replacement. International Journal of Cancer 129: 1018-1029 (Selected as a featured article in spotlight)

(61)Lee, Y.-J., Han, S.-R., Maeng, J-S., Cho, Y-J., and Lee, S.-W. (2012). In vitro selection of Escherichia coli O157:H7-specific RNA aptamer. Biochemical and Biophysical Research Communications 417: 414-420.

(62)Lee, Y.-J., and Lee, S.-W. (2012). Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein. Biochemical and Biophysical Research Communications 417: 521-527.

(63)Lee, C.-H., Kim, J.-H., Kim, H.-W., Myung, H,-J., and Lee, S.-W. (2012). Hepatitis C Virus Replication-Specific Inhibition of MicroRNA Activity with Self-Cleavable Allosteric Ribozyme. NUCLEIC ACID THERAPEUTICS 22: 17-29.

(64)Won, Y.-S., and Lee, S.-W. (2012). Cancer-Specific Induction of Adenoviral E1A Expression by Group I Intron-Based Trans-Splicing Ribozyme. J. Microbiol.Biotechnol. 22: 431-435.

(65)Won, Y.-S., and Lee, S.-W. (2012). Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme. Journal of Biotechnology 158: 44-49.

(66)Lee Y.-J., Han S.-R., Kim N.-Y., Lee S.-H., Jeong J.-S., and Lee, S.-W. (2012). An RNA Aptamer Taht Binds Carcinoembrypnic Antigen Inhibits Hepatic Metastasis of Colon Cancer Cells in Mice. Gastroenerology. 143: 155-165.(Selected and invited as Video Abstract)

(67)Maeng J.-S., Kim N.S., Kim C.-T., Han S.-R., Lee Y.-J., Lee S.-W. Lee M.-H., and Cho, Y.-J. (2012). Rapid Detection of Food Pathogens Using RNA Aptamers-Immobilized Slide. J. Nanosci. Nanoechnol. 12: 5138-5142.

(68) Kwon, T., Park, J., Lee, G., Nam, K., Huh, Y.-M., Lee, S.-W., Yang, J., Lee, C. Y., Eom, K. (2013) Carbon nanotube-patterned surface-based recognition of carcinoembryonic antigens in tumor cells for cancer diagnosis. Journal of Physical Chemistry Letters 4: 1126-1130.

(69)Hong H.-W., Lee S.-W.., Myung H. (2013). Induced degradation of Tat by nucleocapsid (NC) via the proteasome pathway and its effect on HIV transcription Viruses 5: 1143-1152.

(70)Lee, C. H., Lee, Y. J., Kim, J. H., Lim, J. H., Kim, J.-H., Han, W., Lee, S.-H., Noh,G.-J., and Lee S.-W. (2013) Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase. Journal of Virology. 87:7064-7074. (Selected as ‘Press Release’ by American Society for Microbiology, Selected in 'Highlights' section in the journal 'Microbe 2013, Vol. 8, No. 6, Page 241')

(71)Han, S. R., and Lee, S.-W. (2013) In vitro selection of RNA aptamer specific to Salmonella Typhimirium. Journal of Microbiology and Biotechnology 23: 878-884.

(72)Lee, C. H., and Lee, S.-W. (2013) Colony forming assay for HCV-replicon cell line. Bio-Protocol 3(24). (Featured protocol under the field of 'Microbiology')

(73)Lee, C. H., Kim, J. H., and Lee S.-W. (2013) Prospects for nucleic acid-based therapeutics against hepatitis C virus. World Journal of Gastroenterology 19(47): 8949-8962.

(74)Lee, S.-W., and Jeong J. S. (2014) Use of tumor-targeting trans-splicing ribozyme for cancer treatment. Methods in Molecular Biology 1103: 83-95.

(75)Kim, Y.-H., Moon, J. Y., Kim, E.-O., Lee, S. J., Kang, S.H., Kim, S. K., Heo, K., Lee, Y., Kim, H., Kim, K. T., Kim, D., Song, M. S., Lee S.-W.., Lee, Y., Koh, S. S., and Kim, I.-H. (2014) Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA retardation in pancreatic cancer mouse model. Cancer Letters. 344: 223-231.

(76)Han, S. R., and Lee S.-W. (2014) In vitro selection of RNA aptamer specific to Staphylococcus aureus. Annals of Microbiology. 64: 883-885.

(77)Han, S. R., Yu, J., and Lee S.-W. (2014) In vitro selection of RNA aptamers that selectively bind danofloxacin. Biochemical and Biophysical Research Communications. 448: 397-402.

(78)Lee, C. H., Kim, J. H., and Lee, S.-W. (2014) The role of microRNAs in hepatitis C virus replication and related liver diseases. The Journal of Microbiology 52(6): 445-451.

(79)Kim, S. J., and Lee S.-W. (2014) Selective expression of transgene using hypoxia-inducible trans-splicing group I intron ribozyme. Journal of Biotechnology. 192:22-27.

(80)Kim, J. H., Jeong, S., Kertsburg, A., Soukup, G. A., and Lee S.-W. (2014) Conditional and Target-Specific Transgene Induction through RNA Replacement Using an Allosteric Trans-Splicing Riboyzme. ACS chemical biology. 9:2491-2495.

(81)Won, Y. S., Jeong, J-S., Kim, S. J., Ju, M. H., and Lee S.-W. (2015) Targeted anticancer effect through microRNA-181a regulated tumor-specific hTERT replacement. Cancer Letters. 356:918-928.

(82)Lee, C. H., Kim, H. W., Kim, T., and Lee S.-W. (2015) Recombinant adenovirus infection suppresses hTERT expression through virus-associated RNA-mediated induction of type 1 interferon. Biochemical and Biophysical Research Communications. 458:830-835.

(83)Kim, J. H., Won, R., Ban, G., Ju, M. H., Cho, K. S., Han, S. Y., Jeong, J-S., and Lee S.-W. (2015) Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation. Scientific Reports. 5:12315.

(84)Kim, S. J., Lee, C. H., and Lee S.-W. (2015) Targeting the MicroRNA Passenger Strand for regulating Therapeutic Transgenes. Nucleic Acid Therapeutics. 25:209-218.

(85)Lee, C. H., Lee, S-H., Kim, J. H., Noh, Y-H., Noh, G-J., and Lee S.-W. (2015) Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein. Molecular Therapy-Nucleic Acids. 4:e254.

(86)Kim, Y.-H., Kim, K. T., Lee, S.-J., Hong, S.-H., Moon, J. Y., Yoon, E. K., Kim, S., Kim, E. O., Kang, S. H., Kim, S. K., Choi, S. I., Goh, S. H., Kim, D., Lee S.-W. Ju, M. H., Jeong, J. S., and Kim, I.-H. (2016) Image-guided suicide gene therapy utilizing multifunctional hTERT-targeting adenovirus for clinical translation in hepatocellular carcinoma. Theranostics. 6(3): 357-368. doi: 10.7150/thno.13621.

(87)Lee, C. H., Han, S. R., and Lee S.-W. (2016) Therapeutic applications of aptamer-based riboswitches. Nucleic Acid Therapeutics. 26(1); 44-51.

(88)Kim, J. H., Lee, C. H., and Lee S.-W. (2016) Hepatitis C virus infection stimulates transforming growth factor-b1 expression through up-regulating miR-192. Journal of Microbiology. 54(7): 520-526.

(89)hang, H. E., Hong, Y. J., Kim, H., Hwang, S. M., Park, J. S., Lee S.-W. Song, E. Y., Park, K. U., Song, J., and Han, K.-s. (2016)Genotyping of 19 red cell antigens, including RHD, using liquid bead arrays. Clinica Chimica Acta. 462: 111-117.

(90)Han, S. R., and Lee S.-W. (2017) Inhibition of Japanese encephalitis virus (JEV) replication by specific RNA aptamer against JEV methyltransferase.Biochemical and Biophysical Research Communications. 483: 687-693.

(91)Kim, S. J., Kim, J. H., Yang, B., Jeong, J.-S., and Lee S.-W. (2017) Specific and efficient regression of cancers harboring KRAS mutation by targeted RNA replacement. Molecular Therapy. 25(2): 356-367.

(92)Lee, C. H., Kim, J. H., and Lee S.-W. (2017) The role of microRNA in pathogenesis and as markers of HCV chronic infection. Current Drug Targets. 8(7): 756-765.

(93)Lee, J. H.,, and Lee S.-W. (2017) The roles of carcinoembryonic antigen in liver metastasis and therapeutic approaches. Gastroenterology Research and Practice. 2017, 7521987; doi: 10.1155/2017/7521987.

(94)Sah, S. K., Kim, H. Y., Lee, J. H., Lee S.-W. Kim, H.-S., Kim, Y.-S., Kang, K.-S., and Kim, T.-Y. (2017) Effects of human mesenchymal stem cells co-culture on calcium-induced differentiation of normal human keratinocytes. Stem Cells. 35: 1592-1602.


   
    국내전문학술지
   

(1) Lee, S.-W., Kim, Y.S., and Kang, H.S. (1987). The Replication of Parvovirus KBSH DNA in the Embryonic Swine Kidney Cells. Korean Journal of Microbiology 25: 34-39.

(2) Lee, S.-W. (1997). Adenovirus and adeno-associated virus as vectors for gene transfer. 생화학, 분자생물학 소식 4: 10-16.

(3) Hwang, B., and Lee, S.-W. (1998). Oligonucleotide Library를 사용한 특이성 리간드개발. 화학세계 38: 47-52.

(4) Lee, S.-W. (1998). Analysis of intracellular expression level of modified tRNA-based foreign transcripts. 단국대학교 교수논문집 33: 119-133.

(5) Lee, S.-W. (1999). Effects of substrate RNA structure on the trans-splicing reaction by group I intron of Tetrahymena thermophila. The Korean Journal of Microbiology 35: 211-217.

(6) Lee, S.-W. (1999). Inhibition of HIV-1 transactivation in latently infected monocytic cells with RNA decoys. 단국대학교 교수논문집 34: 221-231.

(7) 이성욱. (2003) 생명의 기원과 유전자 비밀 밝혀줄 핵심분자 RNA. In 과학동아. Seoul, Korea. 4월호. pp85-89.

(8) 이성욱. (2003) ‘유전비밀의 실체’ 재조명되는 세포정보 RNA. In 과학과 기술. Seoul, Korea. 3월호. pp42-45.

(9) Hyun, J. W., Ahn, Y., Hwang, C.-S., Lee, S.-W., and Chu, H.-E. (2003) A study on the development of an interdisciplinary curriculum for the nano-science major system
in college. 한국물리학회지 (새물리) 47: 10-20.

(10) Lee, S.-W. (2003). Inhibition of HIV-1 replication in CD4+ peripheral blood lymphocytes by intracellular expression of RNA aptamer. The Korean journal of Microbiology 39: 235-241.

(11) Jung, H.-S., and Lee, S.-W. (2004). Ribozymes; Recent advances as tools for molecular medicine. Journal of Nano & Bio Tech 1: 14-20.

(12)Park, Y.-H., Kim, S.-C., Kwon, B.-S., Jung, H.-S., Kimm, K., and Lee, S.-W. (2004) Functional modification of a specific RNA with targeted trans-splicing. Genomics & Informatics 2: 45-52.

(13)Song, M.-S., and Lee, S.-W. (2004). Tumor specific cancer gene therapy. Journal of Nano & Bio Tech 1: 73-88.

(14) Kwon, B.-S., and Lee, S.-W. (2005). Promising potential of allosteric ribozyme in bio-nano technology. Journal of Nano & Bio Tech 2: 10-16.

(15) Lee, Y. J., and Lee, S.-W. (2005). Massive identification of cancer-specific nucleic acid ligands. Genomics & Informatics 3: 77-80.

(16) Jung, H-S., Kwon, B.-S., and Lee, S.-W. (2005). Specificity of intracellular trans-splicing reaction by Tetrahymena group I intron. Journal of Nano & Bio Tech 2: 76-79.

(17) Jung, H-S., Kwon, B.-S., and Lee, S.-W. (2005). Specificity of intracellular trans-splicing reaction by hTERT-targeting group I intron. Genomics & Informatics 3: 172-174.

(18) Song, M.-S., and Lee, S.-W. (2007). An RNA mapping strategy to identify ribozyme-accessible sites on the catalytic subunit of mouse telomerase. Genomics & Informatics 5: 32-35.

(19) Lee, S.-W. (2007). Ribozyme as a molecular therapeutic agent. 대한 생화학, 분자생물학회 소식 14: 33-40.

(20) Lee, S.-W. (2007). Ribozyme as therapeutic tool. 분자세포생물학뉴스 19: 30-37.

(21) Won, Y.-S., and Lee, S.-W. (2007) Oncolytic adenoviruses for cancer therapy. Journal of Nano & Bio Tech 4: 15-18.

(22) Lee, C. H., and Lee, S.-W. (2007). Development of hepatitis C virus (HCV) genome-targeting hammerhead ribozyme which activity can be allosterically regulated by HCV NS5B RNA replicase. The Korean Journal of Microbiology 43: 159-165.

(23) Song, M.-S., and Lee, S.-W. (2008). In vivo target RNA specificity of trans-splicing phenomena by the group I intron. Genomics & Informatics 6: 84-86.

(24) Song, M.S., Jeong, J.-S., and Lee, S.-W. (2008) Inhibition of telomerase expression in vivo by hTERT targeting trans-splicing ribozyme. Journal of Nano & Bio Tech 5: 14-17.

(25) Song, M.S., Jeong, J.-S., and Lee, S.-W. (2008) Inhibition of telomerase expression in vivo by hTERT targeting trans-splicing ribozyme. Journal of Nano & Bio Tech 5: 14-17.

(26) Kim, J.H., Ban, G., Won, Y.S., Kim, S.J., Won, R., and Lee, S.-W. (2009) Trans-splicing reaction in cells by mTERT-targeting group I intron. Journal of Nano & Bio Tech 6: 15-18.

(27) Song, M.-S., and Lee, S.-W. (2009) RNA mapping of mutant myotonic dystrophy protein kinase 3'-untranslated region transcripts. Genomics & Informatics 7: 181-186. (Selected as cover featured article)

(28) Ban, G., Kim, A., Kim, S., and Lee, S.-W. (2010) Accurate trans-splicing reaction in vivo by hCKAP2-targeting group I intron ribozyme. Journal of Nano & Bio Tech 7: 6-9.

(29) Lee, C. H., and Lee, S.-W. (2011) Inhibition of hepatitis C virus (HCV) replication by hammerhead ribozyme which activity can be allosterically regulated by HCV NS5B RNA replicase. The Korean Journal of Microbiology. 47: 188-193.

(30) Ban, G., Jeong, J.-S., and Lee, S.-W. (2011) In vivo target specificity of hCKAP2-replacing trans-splicing ribozyme. Journal of Nano & Bio Tech. 8: 10-13.

(31) Lee, S.-W. (2013) 유전자 치료제 개발 동향 분석. 신약개발연구동향. Bioin 스페셜 웹진. 35호.

(32) Lee, C. H., Kim, J. H., and Lee, S.-W. (2013) Aptamers as therapeutic agents against hepatitis C virus. Journal of Nano & Bio Tech. 10: 7-10.


     
  저서
    (1) Lee, S.-W., and Sullenger, B. (1998) Trans-splicing ribozymes as potential HIV gene inhibitors. In Gene Therapy for HIV Infection. Smith, C. (ed.). Springer, Heidelberg, Germany. pp. 49-58.

(2) Lee, S.-W. (1998). Adenovirus and adeno-associated virus as vectors for gene transfer. In Trends in Medical Research. Korean Society of Medical Biochemistry and Molecular Biology Publishers, Seoul, Korea. pp 169-175.

(3) Lee, S.-W. (2000) Oligonucleotide library. In Molecular Biomethods for Cancer Research. 박재갑. (ed.) 도서출판 의학문화사, Seoul, Korea. pp. 251-259.

(4) Lee, S.-W. (2000) Adeno-associated viral vector system. In Gene Therapy. Korean Society of Medical Biochemistry and Molecular Biology Publishers, Seoul, Korea. pp 25-37.

(5) 이성욱 외 13인 공저. (2001) 생명과학. 단국대학교출판부. Seoul, Korea.

(6) 이성욱 외 9인 공저. (2003) 아데노수반바이러스 벡터. In 유전자 치료. 군자출판사. Seoul, Korea. pp 137-178.

(7) 이성욱 외 5인 공저. (2006) 나노의 세계. (주)북스힐. Seoul, Korea.

(8) Lee, S.-W. (2011) Introducing the Korean Oligonucleotide Therapeutics Society. Nucleic Acid Therapeutics. 21: 123.

(9) Lee, C. H., Kim, J. H., and Lee, S.-W. (2013) Prospects for nucleic acid-based therapeutics against hepatitis C virus. In World Clinical Gastroenterology Ma, L. et al.(ed.). Baishideng Publishing Group Inc., Pleasanton, CA, U.S. pp. 2645-2658.

(10) 이성욱 외 66인 공저. (2017) 미생물학. (주)범문에듀케이션. Seoul, Korea (2017. 09. 01).

     
  특허
    등록
    (1) 이성욱, 유재훈, 박호군, 최소영. 아미노-RNA에 대한 항체 및 이의 제조방법 [국내특허등록 10-0341827 (2002년 6월 11일)]

(2) 이성욱, 황병훈, 여현주. C형 간염 바이러스 증식조절단백질에 특이적으로 결합하는 RNA 및 이를 이용한 HCV 감염 진단용 키트 [국내특허출원 10-2000-0047473 (2000년 8월 17일): 국내특허등록 10-0390371 (2003년 6월 25일)]

(3) 이성욱, 박중찬, 배수진, 엄지현. 엔에프에이티씨에 특이적으로 결합하는 알엔에이 [국내특허 출원 10-2002-0019425 (2002년 4월 10일): 국내특허등록 10-0468388 (2005년 1월 18일)]

(4) 이성욱, 유경주. C형 간염 바이러스의 IRES 발현 세포에서만 선택적으로 유전자 활성을 유 도하는 트랜스-스플라이싱 리보자임 [국내특허출원 10-2002-0060839 (2002년 10월 5일): 국내특허등록 10-0490699 (2005년 5월 12일)]

(5) 이성욱, 이윤식, 김남연, 이영주. 씨이에이의 암 전이 유도 도메인에 특이적으로 결합하는 알엔에이 압타머 [국내출원 10-2005-0093871 (2005년 10월 6일); 국내특허등록 10-0667009 (2007년 1월 4일)] (Inventor; 이성욱, 이윤식, 김남연, 이영주)

(6) 이성욱, 신경숙, 임종훈, 이영주, 이창호. 씨형 간염 바이러스 레플리콘 증식을 억제하는 알엔에이 분해효소 저항성 알엔에이 압타머 (Nuclease-resistant RNA aptamer inhibiting replication of hepatitis C virus replicon) [국내출원 10-2006-0118062 (2006년 11월 28일), 10-2007-0054744 (2007년 6월 5일); 국내특허등록 10-0861108 (2008년 09월 24일)]

(7) 이성욱, 김인후, 홍승희, 정진숙, 이윤종, 이연수, 정행임. 라이보자임을 함유한 아데노바이러스를 이용한 질병의 분자영상진단법 (A method for diagnosing disease using adenovirus harboring trans-splicing ribozyme by molecular imaging) [국내출원 10-2007-0107828 (2007년 10월 25일); 국내특허등록 10-0907106 (2009년 07월 02일)]

(8) 이성욱, 이창호. HCV NS5B 의존적인 앱타자임 및 이를 이용한 HCV의 진단 방법 (HCV NS5B dependent aptazyme and diagnosis method of HCV using same) [국내출원 10-2008-0027525 (2008.03.25)]; 국내특허등록 10-0956328 (2010년 04월 28일)]

(9) 이성욱, 장선영, 김주현. 테오필린에 의해 표적 특이적 RNA 치환 활성이 조절되는 알로스테릭 트랜스-스플라이싱 그룹 I 리보자임 (Allosteric trans-splicing group I ribozyme whose activity of target-specific RNA replacement is controlled by theophylline) [국내출원 10-2008-0028483 (2008.03.27); 국내특허등록 10-0958293 (2010.05.10)]

(10) 이성욱, 송민선, 김인후, 정진숙. 조직 특이적 프로모터와 암 특이 유전자를 타겟팅하는 트랜스-스플라이싱 라이보자임을 포함하는 재조합 아데노바이러스 및 이의 용도 (Recombinant adenovirus comprising tissue-specific promoter and tumor-targeted trans-splicing ribozyme and uses thereof) [국내출원 10-2008-0082732 (2008.08.25); 국내특허등록 10-1034811 (2011.05.06)]

(11) Seong-Wook Lee, Kyung-Sook Shin, Jong-Hoon Lim. Nuclease-resistant RNA aptamer inhibiting replication of hepatitis C virus replicon [PCT/KR2007/002768 (2007.06.08), 미국출원 No. 12/516,311; 미국등록 No. US 8,008,272 (2011.08.30)]

(12) Seong-Wook Lee, Kyung-Sook Shin, Jong-Hoon Lim, Young-Joo Lee, Chang-Ho Lee. Nuclease-resistant RNA aptamer inhibiting replication of hepatitis C virus replicon [PCT/KR2007/002769 (2007.06.08), 유로연합 출원 No. 07793124.4; 유로연합 등록 No.: EP 2 092 078 B1, 스위스, 독일, 프랑스, 영국, 아일랜드, 이태리, 네덜랜드, 스웨덴 (2011.12.01)]

(13) Seong-Wook Lee, Sun Young Jang, Ju Hyun Kim. Allosteric trans-splicing group I ribozyme whose activity of target-specific RNA replacement is controlled by theophylline. [PCT/KR2008/007440 (2008.12.16), 일본출원 No. 2010-506095 (2009.03.24), 일본등록 No.4908631 (2012.01.20)]

(14) Seong-Wook Lee, Kyung-Sook Shin, Jong-Hoon Lim, Young-Joo Lee, Chang-Ho Lee. Nuclease-resistant RNA aptamer inhibiting replication of hepatitis C virus replicon [PCT/KR2007/002768 (2007.06.08), 오스트레일리아 출원 No. 2007326284; 오스트레일리아 등 록 No.: 2007326284 (2012.05.03)]

(15) Seong-Wook Lee, Sung Jin Kim, Ju Hyun Kim, Jin-Sook Jeong. Kras G12V RNA를 특이적으로 인지할 수 있는 트랜스-스플라이싱 그룹 I 리보자임 (Trans-splicing group I ribozyme specific for Kras G12V RNA) [국내출원 10-2008-0110937 (2008.11.10), 국내특허등록 10-1153845 (2012.05.31); 국내출원 10-2012-0039745 (2012.04.17), 국내특허등록 10-1153844 (2012.05.31)]

(16) 이성욱, 한승렬, 유재훈. 항생제 다노플록사신에 특이적으로 결합하는 RNA 앱타머 및 이의 용도 (RNA aptamer binding to danofloxacin with specifically and the use thereof). [국내출원 10-2010-0095518 (2010.09.30), 국내특허등록 10-1216906 (2012.12.21)]

(17) 이성욱, 이창호. HCV 감염 세포에서 특이적으로 마이크로 RNA에 대한 안티센스를 방출하는 엡타자임 및 이를 이용한 HCV 관련 질환 치료용 조성물. (Aptazyme specifically releasing antisense against miRNA in HCV infected cell and Composition for treating HCV related diseases using the same) [국내출원 10-2010-0091145 (2010.09.16), 국내특허등록 10-1218470 (2012.12.27)]

(18) Seong-Wook Lee, Kyung-Sook Shin, Jong-Hoon Lim, Young-Joo Lee, Chang-Ho Lee. Nuclease-resistant RNA aptamer inhibiting replication of hepatitis C virus replicon [PCT/KR2007/002768 (2007.06.08), 캐나다 출원 No. 2670447; 캐나다 등록 No.: 2 670 447 (2013.02.12)]

(19) Seong-Wook Lee, In-Hoo Kim, Seung-Hee Hong, Jin-Sook Jeong, Yoon-Jong Lee, Yeon-Su Lee, Haeng-Im Jung. A method for diagnosing disease using adenovirus harboring trans-splicing ribozyme by molecular imaging. [일본 등록 No.: 5290208 (2013.06.14)]

(20) Seong-Wook Lee, In-Hoo Kim, Seung-Hee Hong, Jin-Sook Jeong, Yoon-Jong Lee, Yeon-Su Lee, Haeng-Im Jung. A method for diagnosing disease using adenovirus harboring trans-splicing ribozyme by molecular imaging. [USA Application No. 12/522,597 (2009.07.09); USA 등록 No.: 8541237 (2013.09.24)]

(21) Seong-Wook Lee, Sun Young Jang, Ju Hyun Kim. Allosteric trans-splicing group I ribozyme whose activity of target-specific RNA replacement is controlled by theophylline. [China Application No. 200880000802.5 (2008.12.16); China 등록 No. ZL200880000802.5 (2014.02.19.)]

(22) 이성욱, 장병용, 이창호. 표적 물질 특이적으로 siRNA를 방출하는 RNA 간섭용 조성물 및 이를 이용한 HCV 관련 질환 치료용 조성물 (Composition for RNA interference releasing siRNA target molecule-specifically and composition for treating HCV related diseases using the same). [국내출원 10-2011-0050323 (2011.05.26), 국내특허등록 10-1384860 (2014.04.07)]

(23) 이성욱, 이상진, 김윤희, 김인후, 정진숙, 한상영. 안전성 및 항암활성이 증가된 재조합 아데 노바이러스 및 이의 용도 (Recombinant adenovirus with enhanced safety and anti-cancer activity and use thereof). [국내출원 10-2012-0132289 (2012.11.21), 국내특허등록 10-1429696 (2014.08.06)]

(24) 이성욱, 정진숙, 김주현, 원유섭. 마이크로RNA를 이용한 조절을 통한 암 특이적 유전자 치료제 (Cancer gene therapeutic agent through regulation using microRNA). [국내출원 10-2011-0050324 (21011.05.26), 국내특허등록 10-1478869 (2014.12.26.)]

(25) Seong-Wook Lee, Youngju Lee, Jin-Sook Jeong. RNA aptamer specifically binding to carcinoembryonic antigen and use thereof. [USA Application No. 61/160,912 (Provisional) (2009.03.17.), No. 12/725,529 (2010.03.17.), No. 13/241,259 (CIP Application) (2011.09.23.); USA 등록 No. 8,927,512 B2 (Date: 2015.01.06)]

(26) 이성욱, 원유섭. AIMP2 유전자의 스플라이싱 변이체 특이적인 트랜스-스플라이싱 활성 을 갖는 핵산 분자 및 이를 이용한 폐암 치료용 약학 조성물 및 폐암 진단용 조성물 (Trans-splicing enzymatic nucleic acid molecule specific to splicing variant of AIMP2 gene, and pharmaceutical composition for treating lung cancer and composition for diagnosing lung cancer using the same). [국내출원 10-2012-0041748 (2012.04.20), 국내특허등록 10-1500804 (2015.03.03)]

(27) 이성욱, 이영주,한승렬,조용진,김남수,김철진,김종태,맹진수. 포도상구균의 테이코산에 대한 RNA 앱타머 (RNA aptamers for teichoic acid of Staphylococcus). [국내출원 10-2010-0129767 (2010.12.17), 국내특허등록 10-1508219 (2015.03.27)]

(28) 이성욱, 이상진, 김인후, 김윤희, 정진숙. 신규한 조건부-복제 가능 아데노바이러스 및 그의 제조 방법 (Novel conditionally-replication-competent-adenovirus and method of producing the same). [국내출원 10-2012-0109751 (2012.10.02), 국내특허등록 10-1522341 (2015.05.12)]

(29) 이성욱, 이영주,한승렬,조용진,김남수,김철진,김종태,맹진수. 살모넬라 티피뮤리움 균주의 ompC 단백질에 대해 결합하는 RNA aptamer (RNA aptamers for Salmonella typhimirium ompC proteins). [국내출원 10-2010-0129763 (2010.12.17), 국내특허등록 10-1535892 (2015.07.06)]

(30) Seong-Wook Lee, Chang Ho Lee. Aptazyme capable of selective silencing of target miRNA by releasing an antisense sequence in hepatitis C virus-infected cells and use thereof. [US Application No. 13/823,845 (2013.03.15)]; US 등록 No. 9,284,555 (2016.03.15.)]

(31) Seong-Wook Lee, Won Il Lee, Seung Ryul Han. 신규한 RNA 앱타머 및 그의 용도 (Novel RNA aptamers and the uses thereof). [국내출원 10-2013-0150232 (2013.12.04.), 국내특허등록 10-1665165 (2016.10.05.)]

(32) 이성욱, 김성진. 치료 유전자의 선택적 발현을 위한 DNA 구조체 (DNA structure for selective expression of therapeutic gene). [국내출원 10-2015-0024366 (2015.02.17.), 국내특허등록 10-1673071 (2016.10.31.)]

(33) 이성욱, 이창호. C형 간염 바이러스의 코어 부위를 표적으로 하는 트랜스-스플라이싱 라이보자임 및 이의 용도 (Hepatitis C virus core targeting trans-splciing ribozyme and use thereof). [국내출원 10-2014-0130287 (2014.09.29), 10-2015-0137740 (2015.09.30.), 국내특허등록 10-1679404 (2016.11.18.)]

(34) 이성욱, 김주현, 정진숙, 한상영. 암 특이적 트랜스-스플라이싱 라이보자임 및 이의 용도 (Tumor-targeting trans-splicing ribozyme and use thereof). [국내출원 10-2014-0130286 (20140.09.29), 10-2014-0185976 (2014.12.22.), 국내특허등록 10-1712247 (2017.02.24.)]

(35) 이성욱, 양빛나, 김성진, 한승렬. 키메릭 항원 수용체(Chimeric antigen receptor) 전달용 CTLA-4 타겟팅 트랜스-스플라이싱 라이보자임 및 이의 용도 (CTLA-4 targeting trans-splicing ribozyme for delivering chimeric antigen receptor and use thereof). [국내출원 10-2015-0016152 (2015.02.02.), 10-2016-0012804 (2016.02.02.), 국내특허등록 10-1755431 (2017.07.03.)]


    출원
    (1) Seong-Wook Lee, Bruce Sullenger, Ning Lan, Lynn Milich. Nucleic Acid Mediated RNA Tagging and RNA Revision [U.S. Patent Application No. 20030036517, Filed 12/3/98, Opened 2/20/03]

(2) Seong-Wook Lee, Kyung-Sook Shin, Jong-Hoon Lim, Young-Joo Lee, Chang-Ho Lee. Nuclease-resistant RNA aptamer inhibiting replication of hepatitis C virus replicon. [일본 (2009-539170), 중국 (200780044401.5), 인도 (3357/DELMP/2009). PCT Application No. PCT/KR2007/002769 (2007.06.08)]

(3) Seong-Wook Lee, In-Hoo Kim, Seung-Hee Hong, Jin-Sook Jeong, Yoon-Jong Lee, Yeon-Su Lee, Haeng-Im Jung. A method for diagnosing disease using adenovirus harboring trans-splicing ribozyme by molecular imaging. [PCT Application No. PCT/KR2007/005334 (2007.10.26)]

(4) Seong-Wook Lee, Min-Sun Song, Jin-Sook Jeong, In-Hoo Kim. Recombinant adenovirus comprising tissue-specific promoter and tumor-targeted trans-splicing ribozyme and uses thereof. [PCT Application No. PCT/KR2008/005030 (2008.08.27)]

(5) Seong-Wook Lee, Sun Young Jang, Ju Hyun Kim. Allosteric trans-splicing group I ribozyme whose activity of target-specific RNA replacement is controlled by theophylline. [PCT Application No. PCT/KR2008/007440 (2008.12.16)]

(6) Seong-Wook Lee, Sun Young Jang, Ju Hyun Kim. Allosteric trans-splicing group I ribozyme whose activity of target-specific RNA replacement is controlled by theophylline. [USA Application No. 12/442,258 (2009.03.20)]

(7) Seong-Wook Lee, In-Hoo Kim, Seung-Hee Hong, Jin-Sook Jeong, Yoon-Jong Lee, Yeon-Su Lee, Haeng-Im Jung. A method for diagnosing disease using adenovirus harboring trans-splicing ribozyme by molecular imaging. [EP Application No. 07833642.7 (2009.07.10)]

(8) Seong-Wook Lee, In-Hoo Kim, Seung-Hee Hong, Jin-Sook Jeong, Yoon-Jong Lee, Yeon-Su Lee, Haeng-Im Jung. A method for diagnosing disease using adenovirus harboring trans-splicing ribozyme by molecular imaging. [Canada Application (2009.07.10)]

(9) Seong-Wook Lee, In-Hoo Kim, Seung-Hee Hong, Jin-Sook Jeong, Yoon-Jong Lee, Yeon-Su Lee, Haeng-Im Jung. A method for diagnosing disease using adenovirus harboring trans-splicing ribozyme by molecular imaging. [China Application (2009.07.17)]

(10) Seong-Wook Lee, Min-Sun Song, Jin-Sook Jeong, In-Hoo Kim. Recombinant adenovirus comprising tissue-specific promoter and tumor-targeted trans-splicing ribozyme and uses thereof. [USA Application No. 12/599,671 (2009.11.10)]

(11) Seong-Wook Lee, Min-Sun Song, Jin-Sook Jeong, In-Hoo Kim. Recombinant adenovirus comprising tissue-specific promoter and tumor-targeted trans-splicing ribozyme and uses thereof. [Japan Application No. 2010-526826 (2009.11.30)]

(12) 이성욱,이영주,한승렬,조용진,김남수,김철진,김종태,맹진수. 이콜라이 O157:H7 균주에 대한 RNA 앱타머 (RNA aptamers for E. coli O157:H7). [국내출원 10-2010-0129765 (2010.12.17)]

(13) 이성욱,김민중. 신규한 RNA 앱타머 및 그의 용도 (Novel RNA aptamers and the Uses thereof). [국내출원 10-2011-0035378 (2011.04.15)]

(14) Seong-Wook Lee, Chang Ho Lee [HCV 감염 세포에서 특이적으로 마이크로 RNA에 대 한 안티센스를 방출하는 엡타자임 및 이를 이용한 HCV 관련 질환 치료용 조성물. (Aptazyme specifically releasing antisense against miRNA in HCV infected cell and Composition for treating HCV related diseases using the same)]. [PCT Application No. PCT/KR2011/006856 (2011.09.16)]

(15) Seong-Wook Lee, Youngju Lee, Seung Ryul Han, Yong Jin Cho, Chul Jin Kim, Nam Soo Kim, Chong Tai Kim, Jin Soo Maeng. 살모넬라 티피뮤리움 균주의 ompC 단백질에 대해 결합하는 RNA aptamer (RNA aptamers for Salmonella typhimirium ompC proteins). [PCT Application No. PCT/KR2011/009629 (Date: 2011.12.14)]

(16) Seong-Wook Lee, Youngju Lee, Seung Ryul Han, Yong Jin Cho, Chul Jin Kim, Nam Soo Kim, Chong Tai Kim, Jin Soo Maeng. 이콜라이 O157:H7 균주에 대한 RNA 앱타머 (RNA aptamers for E. coli O157:H7). [PCT Application No. PCT/KR2011/009630 (Date: 2011.12.14)]

(17) Seong-Wook Lee, Youngju Lee, Seung Ryul Han, Yong Jin Cho, Chul Jin Kim, Nam Soo Kim, Chong Tai Kim, Jin Soo Maeng. 포도상구균의 테이코산에 대한 RNA 앱타머 (RNA aptamers for teichoic acid of Staphylococcus). [PCT Application No. PCT/KR2011/009631 (Date: 2011.12.14)]

(18) Seong-Wook Lee, Ji Young Im, Jin Sook Jeong, Sung Jin Kim. 암특이적 유전자를 표적 하는 트랜스-스플라이싱 라이보자임의 조절 유도체를 포함하는 재조합 아데노바이러스 및 이의 용도 (Recombinant adenovirus comprising regulated derivatives of tumor-targeting trans-splicing ribozyme and uses thereof). [국내출원 10-2013-0099276 (2013.08.21.)]

(19) Seong-Wook Lee, Sang-Jin Lee, Yun-Hee Kim, In-Hoo Kim, Jin Sook Jeong, Sang-Young Han. Recombinant adenovirus with enhanced safety and anti-cancer activity and use thereof. [PCT Application No. PCT/KR2013/010639 (Date: 2013.11.21.)]

(20) Seong-Wook Lee, Sang-Jin Lee, Yun-Hee Kim, In-Hoo Kim, Jin Sook Jeong, Sang-Young Han. Recombinant adenovirus with enhanced safety and anti-cancer activity and use thereof. [U.S. Application No. 14/646,730 (Date: 2013.11.21.)]

(21) Seong-Wook Lee, Sang-Jin Lee, Yun-Hee Kim, In-Hoo Kim, Jin Sook Jeong, Sang-Young Han. Recombinant adenovirus with enhanced safety and anti-cancer activity and use thereof [European Application No. EP2924115 A1 (Date: 2013.11.21.)]

(22) 이성욱, 김지현, 이창호. 마이크로RNA-192에 대한 길항제를 포함하는 간 섬유화 억제용 조성물 (Composition comprising antago-miR-192 for inhibiting liver fibrosis). [국내출원 10-2014-0130502 (2014.09.29)]

(23) Seong-Wook Lee, Ju Hyun Kim, Jin-Sook Jeong, Sang Young Han. Tumor-targeting trans-splicing ribozyme and use thereof. [PCT Application No. PCT/KR2015/007694 (Date: 2015.07.23)]

(24) Seong-Wook Lee, it Na Yang, Sung Jin Kim, Seung Ryul Han. CTLA-4 targeting trans-splicing ribozyme for delivering chimeric antigen receptor and use thereof. [PCT Application No. PCT/KR2016/001106 (Date: 2016.02.02)]

(25) 이성욱, 김지현, 이창호. 재조합 간암세포주를 이용하여 다양한 레벨의 miR-122 발현을 조절하는 방법 (Method for regulating different miR-122 expression levels by recombinant hepatocellular carcinoma cell line). [국내출원 10-2016-0118264 (2016.09.13.)]

(26) 이성욱, 정재인, 한승렬. 뎅기바이러스 혈청형 2의 메틸트랜스퍼라제 활성을 억제하는 RNA 앱타머 (RNA aptamers that inhibit methyltransferase activity of Dengue virus serotype 2). [국내출원 10-2016-0135212 (2016.10.18.)]

(27) 이성욱, 정재인, 한승렬. 뎅기바이러스 혈청형 2 및 3의 메틸트랜스퍼라제 활성을 억제하는 RNA 앱타머 (RNA aptamers that inhibit methyltransferase activity of Dengue virus serotype 2 and 3). [국내출원 10-2016-0135213 (2016.10.18.)]

(28) Seong-Wook Lee, Ju Hyun Kim, Jin-Sook Jeong, Sang Young Han. Cancer specific-splicing ribozyme and use thereof. [U.S. Application No. 15/515,266 (Date: 2017.03.29.)]

(29) Seong-Wook Lee, Ju Hyun Kim, Jin-Sook Jeong, Sang Young Han. 암 특이적 트랜스-스플라이싱 라이보자임 및 이의 용도 (Tumor-targeting trans-splicing ribozyme and use thereof). [Japan Application No. 2017-518146 (Date: 2017.03.29.)]

(30) Seong-Wook Lee, Ju Hyun Kim, Jin-Sook Jeong, Sang Young Han. Cancer specific-splicing ribozyme and use thereof. [유로연합 출원 No. EP15847264.7 (Date: 2017.04.27.)]

(31) Seong-Wook Lee, Bit Na Yang, Sung Jin Kim, Seung Ryul Han. CTLA-4 targeting trans-splicing ribozyme for delivering chimeric antigen receptor and use thereof. [U.S. Application No. 15/548,362 (Date: 2017.08.02.)]

(32) 이성욱, 이창호, 한승렬, 김지현. CRISPR 시스템 기능 향상 방법 그의 이용 (Method of CRISPR system enhancement and use thereof). [국내출원 10-2017-0172383 (2017.12.14.)]

(33) 이성욱, 이창호, 한승렬, 김지현. TERT 프로모터 돌연변이에 특이적인 CRISPR 시스템 및 그의 이용 (CRISPR system specific for TERT promoter mutation and use thereof). [국내출원 10-2017-0172385 (2017.12.14.)]


  학술회의발표
    국제학술회의발표
   

(1) Third International Symposium on Catalytic Ribozymes and Targeted Gene Therapy
Intracellular immunization against HIV using RNA decoys. p. 61. USA, 1992.
(Smith, C., Lee, S.-W., Sullenger, B., Gallardo, H., Ungers, G., and Gilboa, E.)

(2) Cold Spring Harbor Symposia on Gene Theapy
Intracellular immunization against HIV using RNA decoys. p. 154. Cold Spring Harbor, NY, USA, Sep. 1992.
(Smith, C., Lee, S.-W., Sullenger, B., Gallardo, H., Ungers, G., and Gilboa, E.)

(3) Journal of Cellular Biochemistry
Intracellular immunization against HIV using RNA decoys. p.S17E. USA, 1993.
(Smith, C., Lee, S.-W., Sullenger, B., Gallardo, H., Ungers, G., and Gilboa, E.) .

(4) UCLA/UCI AIDS Symposium on Gene Therapy Approaches to Treatment of HIV-1 Infection.
Intracellular immunization against HIV using RNA decoys. p. 25. USA, 1993.
(Smith, C., Lee, S.-W., Sullenger, B., Gallardo, H., Ungers, G., and Gilboa, E.)

(5) Cold Spring Harbor Symposium on Gene Therapy
Inhibition of HIV with intracellularly expressed RNA decoys. p.210. Cold Spring Harbor, NY, USA, Sep. 1994.
(Smith, C., Lee, S.-W., Gallardo, H., Phillips, K., Wong, E., Wininger, D., Hiloman-Gasper, O., Page, K., Lebkowski, J., and Gilboa, E.)

(6) Workshop on HIV/SIV pathogenesis and mucosal transmission and AIDS postdoctoral fellows meeting
Inhibition of HIV-1 transactivation in chronically infected monocytic cells by RNA decoys. p.18. USA, 1994.
(Wininger, D., Gilboa, E., Lee, S.-W., Gallardo, H., Wong, E., and Smith, C.)

(7) 1994 Annual Meeting by the Laboratory of Tumor Cell Biology (AIDS Research and Human Retroviruses)
Inhibition of HIV with intracellularly expressed RNA decoys. . Vol. 10. Supplement 3. p. S156. USA, 1994.
(Smith, C., Lee, S.-W., Gallardo, H., Wong, E., Wininger, D., Hiloman-Gasper, O., Page, K., and Gilboa, E.)

(8) RNA '96 The first annual meeting of the RNA society
Isolation of a nuclease resistant decoy RNA that can protect lymphocytes from autoantibodies directed against the human insulin receptors. p. 393. Madison, WI, USA. May 1996.
(Lee, S.-W., and Sullenger, B.)

(9) RNA '96 The first annual meeting of the RNA society
Tagging ribozyme reaction sites to follow trans-aplicing in mammalian cells. p. 694. Madison, WI, USA. May 1996.
(Sullenger, B., Jones, J., and Lee, S.-W.)

(10) Keystone Symposium on Molecular and Cell Biology of Gene Therapy
Ribozyme-mediated repair of mutant RNAs. p. 42. Kyston, CO, USA. Jan. 1998.
(Sullenger, B., Lan, N., Howrey, R., Lee, S.-W., and Smith, C.)

(11) Keystone Symposium on Molecular and Cell Biology of Gene Therapy
Ribozyme-mediated repair of sickle β-globin transcripts. p. 78. Kyston, CO, USA. Jan. 1998.
(Lan, N., Howrey, R., Lee, S.-W., Smith, C., and Sullenger, B.)

(12) 6th IUBMB Seoul Conference
Selection of potent RNA decoys that inhibit HCV RNA helicase. p. 101. Seoul, Korea. Oct. 1999.
(Hwang, B., Chung, K. M., Jang, S. K., and Lee, S.-W.)

(13) 7th International Meeting on Hepatitis C and Related Viruses
Isolation of high affinity RNA aptamers specific for HCV regulatory proteins and their application for in situ diagnosis of the HCV proteins. p. 325. Gold Coast, Queensland, Australia. Dec. 2000.
(Lee, S.-W., Hwang, B., Yeo, H. J., Lim, J. H., Myung, H., and Jang, S. K.)

(14) 4th Annual Meeting of the American Society of Gene Therapy (Oral Presentation)
Ribozyme-mediated selective induction of gene activities in cancer cells by targeted trans-splicing. Molecular Therapy Vol. 3, No. 5, Part 2; S26. Seattle, WA, USA. May 2001
(Jung, H.-S., Kim, S.-C., Kwon, B.-S., Kimm, K., and Lee, S.-W.)

(15) 5th Annual Meeting of the American Society of Gene Therapy
Ribozyme-triggered selective induction of cytotoxin in cancer cells by targeted trans-splicing. Molecular Therapy Vol. 5, No. 5, Part 2; S136-137. Boston, MA, USA. Jun. 2002.
(Kwon, B.-S., Jung, H.-S., Kim, S.-C., Kimm, K., and Lee, S.-W.)

(16) Ribozymes and RNA Catalysis (Biochemical Society Focused Meeting / EMBO Workshop)
Trans-splicing ribozymes that could induce therapeutic gene activities in hepatitis C virus infected cells. p. 17. Dundee, UK. Aug. 2002.
(Ryu, K.-J., Kim, J.-H., and Lee, S.-W.)

(17) The Knowledge Foundation's 2nd International Conference on RNA in Drug Develpment
Trans-splicing ribozymes as specific and selective delivers of therapeutic new gene activities. San Diego, CA, USA. Nov. 2002.
(Lee, S.-W.)

(18) RNA 2003 (8th Annual Meeting of the RNA Society)
Specificity of group I intron-based trans-splicing ribozyme that can selectively induce new gene activities in target RNA-expressing cells. p. 552. Vienna, Austria. July 2003.
(Lee, S.-W., Jung, H.-S., Ryu, K.-J., Kim, J.-H.)

(19) European Society of Gene Therapy 11th Congress
Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme. P225. Edinburgh, U.K. Nov. 2003.
(Song, M.-S., Kwon, B.-S., Jung, H.-S., Kim, I.-H., and Lee, S.-W.)

(20) RNA 2004 (9th Annual Meeting of the RNA Society)
Inhibition of hepatitis C virus replication by specific RNA aptamers. p.231.
Madison, WI, USA. Jun. 2004.
(Kim, J.-H., Lim, J. H., Cho, S., Myung, H., Kim, B.-G., and Lee, S.-W.)

(21) RNA 2004 (9th Annual Meeting of the RNA Society)
Specific cancer cell regression by targeted trans-splicing ribozyme. p.232.
Madison, WI, USA. Jun. 2004.
(Kwon, B.-S., Jung, H.-S., Song, M.-S., Kim, I.-H., and Lee, S.-W.)

(22) 7th Annual Meeting of the American Society of Gene Therapy
Group I intron-mediated trans-splicing revision of mutant p53 transcripts. Minnesota, USA. Jun. 2004.
(Catron, D. J., Watanabe, T., Shin, K.-S., Toloza, E. M., Lee, S.-W., and Sullenger, B. A.)

(23) 7th Annual Meeting of the American Society of Gene Therapy
Feasinility of hTERT-targeting trans-splicing ribozyme in tumor gene therapy. Minnesota, USA. Jun. 2004.
(Hong, S.-H., Lee, Y.-J., Jung, H.-I., Kwon, B.-S., Lee, S.-W., Jeong, J.-S., Kim, C.-M., and Kim, I.-H.)

(24) RNA 2004 International Summer Symposium
Specific cancer gene therapy by targeted trans-splicing ribozyme. pp. 118-127.
Seoul, Korea. July 2004.
(Kwon, B.-S., Jung, H.-S., Song, M.-S., Kim, I.-H., and Lee, S.-W.)

(25) 2004 International Meeting of the Federation of Korean Microbiological Societies (Oral Presentation)
Inhibition of HCV replication by in vitro selected RNA aptamers. pp 90-91.
Seoul, Korea. Oct. 2004.
(Lee, S.-W.)

(26) 연세대학교 생명과학기술 국제심포지움 (New Challenges in the Post Genome Era 2004) (Oral Presentation)
Trans-splicing ribozyme as a new tool for cancer gene therapy. pp 58-59.
Seoul, Korea. Nov. 2004
(Lee, S.-W.)

(27) 55th Annual Meeting of the American Association for the Study of Liver Diseases
Tumor-targeted gene therapy by trans-splicing ribozyme reduced hepatotoxicity in mouse metastatic cancer model
Hepatology Vol. 40, No. 4, Suppl.1, p. 520A
Boston, MA, USA. 20041029-20041102
(Jeong, J.S., Han, S.Y., Lee, S.-W., Kim, I.H.)

(28) 8th Annual Meeting of the American Society of Gene Therapy
Efficacy of group I intron-based trans-splicing ribozyme in tumor-targeted gene therapy. Molecular Therapy Vol. 11, Suppl. 1; S122. St. Louis, MO, US2A. Jun. 2005.
(Kwon, B.-S., Kim, J. H., Jeong, J.-S., Kim, I.-H., and Lee, S.-W.)

(29) 8th Annual Meeting of the American Society of Gene Therapy
Inhibition of hepatitis C virus replication by in vitro selected specific RNA aptamers. Molecular Therapy Vol. 11, Suppl. 1; S379-380. St. Louis, MO, USA. Jun. 2005.
(Kim, J.-H., Kim, N. Y., and Lee, S.-W.)

(30) 13th Annual Congress of the European Society of Gene Therapy
New cancer gene therapy by trans-splicing ribozyme-mediated targeted replacement of hTERT RNA. P055.
Prague, Czech Republic. Oct. 2005.
(Kim, J. H., Kwon, B.-S., Jeong, J.-S., Kim, I.-H., and Lee, S.-W.)

(31) 13th Annual Congress of the European Society of Gene Therapy
Modulation of hepatitis C virus multiplication by specific RNA aptamers against NS5B RNA replicase. P108.
Prague, Czech Republic. Oct. 2005.
(Lee, Y. J., Kim, J.-H., Kim, N. Y., and Lee, S.-W.)

(32) 13th United European Gastroenterology Week
Human telomerase reverse transcriptase targeting trans-splicing ribozyme as tumor-targeted gene therapy and least hepatotoxicity in vivo.
Copenhagen, Denmark. Oct. 2005
(Jeong, J. S., Han, S. Y., Lee, S.-W., Hong, S. H., and Kim, I. H.)

(33) RNA 2005 International Winter Symposium
Reprogramming gene expression by trans-splicing ribozyme: Application to specific and efficient cancer gene therapy.
Seoul, Korea, Dec. 2005
(Lee, S.-W.)

(34) PBC Symposium 2006 "Aptamer - Emerging tool for therapeutics and diagnostics" (Oral Presentation)
Aptamers for antiviral agents as decoys. p.10.
Pohang, Korea, Feb. 17th 2006
(Lee, S.-W.)

(35) 9th Annual Meeting of the American Society of Gene Therapy
Specific cancer regression by trans-splicing ribozyme-mediated replacement of K-RASV12 transcript.
Molecular Therapy Vol. 13, Suppl. 1; S277.
Baltimore, MD, USA. May 31 - Jun 4 (Jun 2), 2006
(Kim, J. H., Kim, S. J., Jang, S. Y., and Lee, S.-W.)

(36) 2nd Meeting of the Oligonucleotide Therapeutics Society (Oral presentation)
Targeted RNA Replacement by trans-splicing ribozyme as specific and efficient cancer gene therapy. New York, NY, USA, Oct. 20, 2006
(Lee, S.-W)

(37) 2nd Meeting of the Oligonucleotide Therapeutics Society
Targeted RNA Replacement by trans-splicing ribozyme as specific and efficient cancer gene therapy. #37. New York, NY, USA, Oct. 19-21, 2006
(Lee, S.-W., Song, M.-S., Won, Y. S., Jeong, J. S., and Kim, I.-H.)

(38) 2nd Meeting of the Oligonucleotide Therapeutics Society
Development and characterization of RNA aptamer specific for carcinoembryonic antigen. #36. New York, NY, USA, Oct. 19-21, 2006
(Lee, Y. J., Kim, N. Y., and Lee, S.-W.)

(39) 2nd Meeting of the Oligonucleotide Therapeutics Society
Selective regression of cancer via tissue-specific expression of hTERT-targeting trans-splicing ribozyme. #57. New York, NY, USA, Oct. 19-21, 2006
(Song, M.-S., Lee, J.-H., Lee, H-N., Byn, J.-H., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(40) 14th Annual Congress of the European Society of Gene Therapy
Specific cancer gene therapy by tissue-specifically targeted RNA replacement. #121. Athens, Greece, Nov. 9-12, 2006
(Lee, S.-W., Song, M.-S., Lee, J.-H., Kim, I.-H., Jeong, J. S.)

(41) The Korean RNA Society (2007년도 한국분자세포생물학회 리보핵산 분과 정기연구회) (Oral presentation)
Allosteric HCV-targeting ribozyme which activity can be modulated by specific RNA aptamer. p11. Seoul, Feb. 27th, 2007
(Lee, C. H., and Lee, S.-W.)

(42) 19th FAOBMB (Federation of Asian and Oceanian Biochemists and Molecular Biologists) Seoul Conference (Oral Presentation)
New liver cancer gene therapy using tissue-specifically targeted RNA replacement. S5-8. Seoul, May 27-30, 2007
(Song, M.-S., Lee, J.-H., Won Y.-S., Cho, K.-S., Jeong, J.-S., Kim, I.-H., and Lee, S.-W.)

(43) 19th FAOBMB (Federation of Asian and Oceanian Biochemists and Molecular Biologists) Seoul Conference
Targeted regression of liver cancer cells by specific replacement of AFP RNA. G-19. Seoul, May 27-30, 2007
(Won, Y.-S., and Lee, S.-W.)

(44) 19th FAOBMB (Federation of Asian and Oceanian Biochemists and Molecular Biologists) Seoul Conference
Engineered allosteric ribozyme which activity is regulated by specific protein aptamer. N-57. Seoul, May 27-30, 2007
(Lee, C. H., and Lee, S.-W.)

(45) American Society of Gene Therapy‘s 10th Annual Meeting
Development of RNA aptamer for human toll-like receptor 2.
Molecular Therapy Vol. 15, Suppl. 1; S268. Seattle, WA, USA. May 30 - Jun 3 (Jun 1), 2007
(Yoo, H., Kong, H. Y., Lee, H.-N., Lee, Y.-J., Lee, S.-W., and Byun, J.)

(46) American Society of Gene Therapy‘s 10th Annual Meeting
Specific and efficient regression of hepatocarcinoma in vivo by liver-specific expression of hTERT-targeting trans-splicing ribozyme.
Molecular Therapy Vol. 15, Suppl. 1; S392. Seattle, WA, USA. May 30 - Jun 3 (Jun 2), 2007
(Song, M.-S., Lee, J.-H., Won, Y.-S., Cho, K.-S., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(47) 3rd Meeting of the Oligonucleotide Therapeutics Society
Trans-splicing ribozyme that can specifically regress cancer cells expressing K-RASV12. #44. Berlin, Germany, Oct. 4-6, 2007
(Kim, S. J., Jang, S. Y., Song, M.-S., and Lee, S.-W.)

(48) 3rd Meeting of the Oligonucleotide Therapeutics Society
RNA aptamers specific to metastasis-stimulating domain of carcinoembryonic antigen. #53. Berlin, Germany, Oct. 4-6, 2007
(Lee, Y. J., Han, S. R., and Lee, S.-W.)

(49) 3rd Meeting of the Oligonucleotide Therapeutics Society
HCV-targeting allosteric ribozyme which activity is modulated by HCV protein. #54. Berlin, Germany, Oct. 4-6, 2007
(Lee, C. H., and Lee, S.-W.)

(50) 3rd Meeting of the Oligonucleotide Therapeutics Society
hTERT-targeting trans-splicing ribozyme as potent anti-cancer agent. #91. Berlin, Germany, Oct. 4-6, 2007
(Won, Y. S., Song, M.-S., Lee, J. H., Jang, S. Y., Ban, G., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(51) 2007 International Meeting of the Federation of Korean Microbiological Societies (Invited Speaker)
Targeted RNA replacement by Tetrahymena group I intron. S15-2
교육문화회관, Oct 11th-12th, 2007
(Lee, S.-W.)

(52) A vison Biomedical Symposium 2008 (RNA world: Small weapons in a big biomedical field) (Invited Speaker)
Targeted and controllable RNA replacement with allosteric trans-splicing ribozyme as a new gene therapeutic approach, Severance hospital, Yonsei Univ., Jan. 17, 2008
(Lee, S.-W.)

(53) The 48th MSK Annual Meeting and 2008 International Symposium on Microbiology (Invited Speaker)
Artificial riboswitch to modulate HCV infection.
pp. 59-61. Daejeon Convention Center, Korea. May 15-16, 2008
(Lee, S.-W.)

(54) The 9th International Congress on Cell Biology & The 20th Annual Conference of the Korean Society for Molecular and Cellular Biology. (Invited Speaker)
Riboswitch as controllable gene therapeutic agent.
S25-8. COEX, Seoul, Korea. Oct. 7-10, 2008
(Lee, S.-W.)

(55) The 9th International Congress on Cell Biology & The 20th Annual Conference of the Korean Society for Molecular and Cellular Biology.
Development and characterization of allosteric ribozyme which activity can be specifically regulated by HCV NS5B protein.
P25-5. COEX, Seoul, Korea. Oct. 7-10, 2008
(Lee, C. H. and Lee, S.-W.)

(56) The 9th International Congress on Cell Biology & The 20th Annual Conference of the Korean Society for Molecular and Cellular Biology.
In vitro selection of specific RNA aptamers to JEV methyltransferase.
P25-8. COEX, Seoul, Korea. Oct. 7-10, 2008
(Han, S. R., Oh, J.-W., and Lee, S.-W.)

(57) The 9th International Congress on Cell Biology & The 20th Annual Conference of the Korean Society for Molecular and Cellular Biology.
Development of controllable siRNA.
P25-9. COEX, Seoul, Korea. Oct. 7-10, 2008
(Lee, J. H., and Lee, S.-W.)

(58) The 9th International Congress on Cell Biology & The 20th Annual Conference of the Korean Society for Molecular and Cellular Biology.
RNA aptamer as a new therapeutic agent against carcinoembryonic antigen inducing hepatic metastasis.
P25-10. COEX, Seoul, Korea. Oct. 7-10, 2008
(Lee, Y. J., Han, S. R., Kim, M. J,, Jeong, J.-S., and Lee, S.-W.)

(59) The 9th International Congress on Cell Biology & The 20th Annual Conference of the Korean Society for Molecular and Cellular Biology.
Development of specific RNA-based cancer gene therapy using trans-splicing ribozyme.
P25-13. COEX, Seoul, Korea. Oct. 7-10, 2008
(Won, Y.-S. and Lee, S.-W.)

(60) The 9th International Congress on Cell Biology & The 20th Annual Conference of the Korean Society for Molecular and Cellular Biology.
CKAP2 RNA-reprogramming trans-splicing ribozymes as specific and efficient cancer gene therapeutic agents.
P5-4. COEX, Seoul, Korea. Oct. 7-10, 2008
(Ban, G., Kim, A., Song, M.-S., and Lee, S.-W.)

(61) The 9th International Congress on Cell Biology & The 20th Annual Conference of the Korean Society for Molecular and Cellular Biology.
Exogenously regulated allosteric trans-splicing ribozyme as target-specific and controllable gene therapeutic agent.
P5-5. COEX, Seoul, Korea. Oct. 7-10, 2008
(Jang, S. Y. and Lee, S.-W.)

(62) The 9th International Congress on Cell Biology & The 20th Annual Conference of the Korean Society for Molecular and Cellular Biology.
Development of specific cancer gene therapy using trans-splicing ribozyme that can specifically reprogram KRASV12 transcript.
P25-5. COEX, Seoul, Korea. Oct. 7-10, 2008
(Kim, S. J., Jeong, J.-S., and Lee, S.-W.)

(63) Dankook Symposium on Molecular Biology: RNA & Diseases (Invited Speaker)
Trans-splicing ribozyme for cancer therapy and molecular imaging.
JNBT Vol. 5, Suppl., pp. 15-25. Dankook University, Yongin, Korea. Oct. 9, 2008
(Lee, S.-W.)

(64) 4th Meeting of the Oligonucleotide Therapeutics Society
Development of RNA aptamers specific for Japanese Encephalitis Virus (JEV) methytransferase.
Boston, USA. Oct. 15-18, 2008
(Han, S. R., Lee, Y. J., Oh, J.-W., and Lee, S.-W.)

(65) 4th Meeting of the Oligonucleotide Therapeutics Society
Tumor specific regression with KRasV12 transcript-replacing trans-splicing ribozyme.
Boston, USA. Oct. 15-18, 2008
(Kim, S. J., Jeong, J.-S., and Lee, S.-W.)

(66) 4th Meeting of the Oligonucleotide Therapeutics Society
Development of aptazyme which activity is modulated by HCV protein.
Boston, USA. Oct. 15-18, 2008
(Lee, C. H. and Lee, S.-W.)

(67) 4th Meeting of the Oligonucleotide Therapeutics Society
RNA aptamer as an efficient inhibitor against CEA-inducing hepatic metastasis.
Boston, USA. Oct. 15-18, 2008
(Lee, Y. J., Han, S. R., Kim, M, j,, Jeong, J,-S,, and Lee, S.-W.)

(68) 4th Meeting of the Oligonucleotide Therapeutics Society
Cancer gene therapy by trans-splicing ribozyme-mediated RNA replacement in cancer cells.
Boston, USA. Oct. 15-18, 2008
(Won, Y.-S. and Lee, S.-W.)

(69) 2008 Annual International Conference in Commemoration of the 60th KSMBMB Anniversary (Invited Speaker)
Ligand-controlled aptazyme as regulator of transgene expression through modulation of RNA processing.
S6-1. Seoul, Korea. Oct. 29-31, 2008
(Lee, S.-W.)

(70) 2nd International Aptamer Symposium. (Invited Speaker)
Inhibition of hepatic metastasis of colon cancer using RNA aptamer.
Dongguk University, Seoul, Korea. Feb. 16, 2009
(Lee, S.-W.)

(71) 7th International RNAi, MicroRNAs & Oligo-2009-Boston Meeting (Invited Speaker)
RNA aptamer as an inhibitor against hepatic metastasis of colon cancer.
Hilton Garden Inn, Waltham, MA, USA. Apr. 1-2, 2009
(Lee, S.-W.)

(72) 2009 Keystone Symposia on Molecular and Cellular Biology: The Biology of RNA Silencing
miRNA inhibition using vector-based anti-miR expression system.
No. 223. Victoria, Columbia, Canada. Apr. 25-30, 2009.
(Lee, C.-H. and Lee, S.-W.)

(73) 2009 Keystone Symposia on Molecular and Cellular Biology: Micro RNA and Cancer
Liver cancer-specific gene induction through microRNA regulation.
No. 109. Keystone, CO, USA. Jun. 10-15, 2009.
(Ban, G., Song, M.-S., Won, Y.-S., Lee, C.-H., and Lee, S.-W.)

(74) 2009 Keystone Symposia on Molecular and Cellular Biology: Micro RNA and Cancer
Putative role of microRNA passenger strand in microRNA pathway.
No. 214. Keystone, CO, USA. Jun. 10-15, 2009.
(Kim, S. J., Won, Y. S., Lee, C. H., and Lee, S.-W.)

(75) 2009 Keystone Symposia on Molecular and Cellular Biology: Micro RNA and Cancer
Specific cancer cell regrsssion with trans-splicing ribozyme which can be specifically regulated by microRNA.
No. 343. Keystone, CO, USA. Jun. 10-15, 2009.
(Won, Y. S., Kim, S. J., and Lee, S.-W.)

(76) 16th International Symposium on Hepatitis C Virus and Related Viruses
Inhibition of hepatitis C virus replication using NS5B-specific RNA aptamers P-213. Nice, France. Oct. 3-7, 2009
(Lee, C. H., Chang, B., and Lee, S.-W.)

(77) 2009 International Symposium of the Pharmaceutical Society of Korea (Invited Speaker)
RNA aptamer an an anti-HCV agent Seoul, Korea. Oct. 15-16, 2009
(Lee, S.-W.)

(78) The 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium (Invited Speaker)
Trans-splicing ribozyme for cancer therapy and molecular imaging
Kyushu University, Fukuoka, Japan. Nov. 3-6, 2009
(Lee, S.-W.)

(79) The 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium (우수포스터상)
Vector-based antimiR expression system which inhibits miRNA function P66.
Kyushu University, Fukuoka, Japan. Nov. 3-6, 2009
(Lee, C. H., Kim, S. J., Won, Y.S., Chang, B., and Lee, S.-W.)

(80) The 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium
RNA-based cancer therapy with trans-splicing ribozyme which expression can be specifically regulated by microRNA P69.
Kyushu University, Fukuoka, Japan. Nov. 3-6, 2009
(Won, Y. S., Kim, S. J., Lee, C. H., Won, R. H., and Lee, S.-W.)

(81) The 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium
Role of microRNA passenger strand in microRNA function P70.
Kyushu University, Fukuoka, Japan. Nov. 3-6, 2009
(Kim, S. J., Won, Y. S., Lee, C. H., and Lee, S.-W.)

(82) The 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium
Development of anti-JEV RNA aptamers P89. Kyushu University, Fukuoka, Japan. Nov. 3-6, 2009
(Han, S. R., Lee, Y. J., Oh, J.-W., and Lee, S.-W.)

(83) The 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium
RNA aptamer as a potent therapeutic lead for hepatic metastasis P90.
Kyushu University, Fukuoka, Japan. Nov. 3-6, 2009
(Lee, Y. J., Han S. R., Kim, M. j., Cho, H., Jeong, J.-S., and Lee, S.-W.)

(84) The 1st Korean Oligonucleotide Therapeutics Society International Symposium : Aptamers and RNAi Therapeutics (Invited Speaker)
RNA aptamers against infectious diseases.
KOFST, Seoul, Korea. Nov. 9th, 2009
(Lee, S.-W.)

(85) The 1st Korean Oligonucleotide Therapeutics Society International Symposium : Aptamers and RNAi Therapeutics
Regulatory activity of microRNA passenger strand.
P.4. KOFST, Seoul, Korea. Nov. 9th, 2009
(Kim, S. J., Won, Y. S., Lee, C. H., and Lee, S.-W.)

(86) The 1st Korean Oligonucleotide Therapeutics Society International Symposium : Aptamers and RNAi Therapeutics
Specific cancer cell regression with trans-splicing ribozyme which can be specifically regulated by microRNA.
P.11. KOFST, Seoul, Korea. Nov. 9th, 2009
(Won, Y. S., Kim, S. J., Lee, C. H., Kim, J. H., Won, R. H., and Lee, S.-W.)

(87) The 1st Korean Oligonucleotide Therapeutics Society International Symposium : Aptamers and RNAi Therapeutics (우수포스터상)
RNA aptamer as a potent inhibitor against hepatic metastasis of colon cancer.
P.13. KOFST, Seoul, Korea. Nov. 9th, 2009
(Lee, Y. J., Han, S. R., Kim, M. J., Cho, H., Jeong, J.-S., and Lee, S.-W.)

(88) The 1st Korean Oligonucleotide Therapeutics Society International Symposium : Aptamers and RNAi Therapeutics
miRNA inhibition using differently localized Pol Ⅲ promoter-based anti-miR expression system.
P.15. KOFST, Seoul, Korea. Nov. 9th, 2009
(Lee, C. H., Kim, S. J., Won, Y. S., Chang, B., and Lee, S.-W.)

(89) The 1st Korean Oligonucleotide Therapeutics Society International Symposium : Aptamers and RNAi Therapeutics
Development of specific RNA aptamer to JEV Methyltransferase as anit-viral therapeutic agent.
P.20. KOFST, Seoul, Korea. Nov. 9th, 2009
(Han, S. R., Lee, Y. J., Kim, M. J., Lee, W. I., Oh, J.-W., and Lee, S.-W.)

(90) 13th Annual Meeting of American Society of Gene & Cell Therapy
Specific and efficacious RNA aptamer against hepatitic metastasis of colon cancer.
No. 560. Washington, DC. USA. May 19th-22nd, 2010
(Lee, S.-W., Lee, Y. J. Han S. R., Kim, M. j., Cho, H., Lee, W. I., and Jeong, J.-S.)

(91) BIT's 1st World Congress of Virus and Infections-2010 (Invited Speaker)
SHV-2010. Track 1-9: New therapies for hepatitis C: Preclinical RNA aptamer as an agent against HCV replication.
Bexco, Busan, Korea. Aug. 3rd, 2010
(Lee, S.-W.)

(92) 17th International Meeting of Hepatitis C Virus and Related Viruses
RNA aptamer against HCV NS5B protein for its therapeutic application.
Yokohama, Japan. Sep. 10th-14th, 2010
(Lee, C. H., Han, W., Lee, S.-H., Lee, Y. J., Kim, J. H., Noh, G.-J., Lee, S.-W.)

(93) The 6th Annual Meeting of the Oligonucleotide Therapeutics Society
Development of JEV MTase specific RNA aptamers for therapeutic agent
No. 026. Dana Point, CA, USA. Oct. 20-23, 2010
(Han, S. R., Lee, Y. J., Kim, M. J., Lee, W. I., Cho, H., Oh, J.-W., and Lee, S.-W.)

(94) The 6th Annual Meeting of the Oligonucleotide Therapeutics Society
Liver cancer-specific gene induction through microRNA regulation.
No. 036. Dana Point, CA, USA. Oct. 20-23, 2010
(Kim, J.-H., Won, R., Won, Y. S., Kim, S., Im, J.-Y., Ban, G., and Lee, S.-W.)

(95) The 6th Annual Meeting of the Oligonucleotide Therapeutics Society
Utility of miRNA passenger strand in miRNA pathway
No. 038. Dana Point, CA, USA. Oct. 20-23, 2010
(Kim, S. J., Won, Y. S., Lee, C. H., and Lee, S.-W.)

(96) The 6th Annual Meeting of the Oligonucleotide Therapeutics Society
Specific targeted gene replacement by microRNA
No. 091. Dana Point, CA, USA. Oct. 20-23, 2010
(Won, Y. S., Kim, S. J., Lee, C. H., Kim, J. H., Won, R. H., Im, J. Y., and Lee, S.-W.)

(97) The 2nd Korean Oligonucleotide Therapeutics Society International Symposium (Oral Presentation)
RNA aptamer as inhibitor against CEA-inducing hepatitis. Seoul National University, Seoul, Korea. Nov. 30th, 2010.
(Lee, Y. J., Han, S. R., Kim, M. J., Cho, H., Jeong, J.-S., and Lee, S.-W.)

(98) The 2nd Korean Oligonucleotide Therapeutics Society International Symposium
In vitro selection of high affinity RNA aptamer to Lin28 and Lin28B.
P.3. Seoul National University, Seoul, Korea. Nov. 30th, 2010.
(Kim, M., Lee, Y. J., Han, S. R., Cho, H., Lee, W., and Lee, S.-W.)

(99) The 2nd Korean Oligonucleotide Therapeutics Society International Symposium
Therapeutic application of HCV NS5B protein specific RNA aptamers
P.8. Seoul National University, Seoul, Korea. Nov. 30th, 2010.
(Lee, C. H., Han, W., Lee, S.-H., Lee, Y., Kim, J. H., Noh, G.-J., and Lee, S.-W.)

(100) The 2nd Korean Oligonucleotide Therapeutics Society International Symposium
Development of RNA aptamer targeting Japanese Encephalitis Virus (JEV) methyltransferase as anti-JEV therapeutic agent.
P.12. Seoul National University, Seoul, Korea. Nov. 30th, 2010.
(Han, S. R., Lee, Y. J., Kim, M. J., Lee, W. I., Cho, H., and Lee, S.-W.)

(101) The 2nd Korean Oligonucleotide Therapeutics Society International Symposium
Identification and characterization of specific RNA aptamer to danofloxacin
P.13. Seoul National University, Seoul, Korea. Nov. 30th, 2010.
(Han, S. R., Lee, Y. J., Kim, M. J., Lee, W. I., Cho, H., Yu, J., and Lee, S.-W.)

(102) International Symposium on Aptamer Technology: Aptamer as an emerging technology for biomedical application (Invited Speaker)
Aptamers for antiviral agents
POSTECH, Pohang, Korea. Dec. 1st, 2010.
(Lee, S.-W.)

(103) The 16th Annual Meeting of the RNA Society and The 13th Annual Meeting of the RNA Society of Japan
Developmenet of Japanese Encephalitis Virus Methyltransferase Specific RNA Aptamers For Anti-viral Agent
No. 162. Kyoto, Japan. June. 14-18, 2011
(Han, S.R., Lee, Y.J., Kim, M.J., Lee, W.I., Lee, S.-W.)

(104) The 16th Annual Meeting of the RNA Society and The 13th Annual Meeting of the RNA Society of Japan
Allosteric ribozyme capable of specifically inhibiting miR-122 functions only in HCV replicating cells (우수포스터상)
No. 166. Kyoto, Japan. June. 14-18, 2011
(Lee, C.H., Kim, J.H., Kim, H.W., Lee, S.-W.)

(105) 7th Annual Meeting of the Oligonucleotide Therapeutics Society
ANTI- CANCER APPROACH THROUGH MICRORNA REGULATED RNA REPLACEMENT
No.36. Copenhagen, Denmark. September. 8-10. 2011
(Kim, J.H., Won, Y.S., Won, R.H., Lee, S.-W.)

(106) 7th Annual Meeting of the Oligonucleotide Therapeutics Society
ALLOSTERIC RIBOZYME CAPABLE OF SPECIFICALLY INHIBITING MIR-122 FUNCTIONS THROUGH HCV NS5B PROTEIN SENSING (student travel grant)
No.40. Copenhagen, Denmark. September. 8-10. 2011
(Lee, C.H., Kim, J.H., Kim, H.W., Lee, S.-W.)

(107) The 23rd Annual Meeting of the Korean Society for Molecular and Cellular Biology
Enhancement of efficacy of trans-splicing ribozyme based on group I intron of Tetrahymean thermophila
A-16. Seoul, Korea. October. 6-7. 2011
(Im, J.Y., Kim, S.J., Lee, S.-W.)

(108) The 23rd Annual Meeting of the Korean Society for Molecular and Cellular Biology
Specific and efficient regression of Hepatocarcinoma through Trans-splicing ribozyme regulated by MicroRNA-122
B-27. Seoul, Korea. October. 6-7. 2011
(Won, R.H., Kim, J.H., Won, Y.S., Lee, S.-W.)

(109) The 23rd Annual Meeting of the Korean Society for Molecular and Cellular Biology
Modulation of colon cancer through miR-192 expression
B-97. Seoul, Korea. October. 6-7. 2011
(Kim, J.H., Lee, C.H., Lee, S.-W.)

(110) The 23rd Annual Meeting of the Korean Society for Molecular and Cellular Biology
Cancer gene therapy based on the cancer-specific RNA replacement by microRNA regulation
B-101. Seoul, Korea. October. 6-7. 2011
(Kim, J.H., Won, Y.S., Won, R.H., Lee, S.-W.)

(111) The 23rd Annual Meeting of the Korean Society for Molecular and Cellular Biology
Genetic system inhibiting miR-122 function specifically in HCV-replicating cells (우수포스터상)
N-11. Seoul, Korea. October. 6-7. 2011
(Lee, C.H., Kim, J.H., Kim, H.W., Lee, S.-W.)

(112) The 3rd Korean Nucleic Acids Society (KNAS) International Symposium
Ectopic expression of miR-192 for the modulation of colon cancer
P.03. Seoul, Korea. October. 31. 2011
(Kim, J.H., Lee, C.H., Lee, S.-W.)

(113) The 3rd Korean Nucleic Acids Society (KNAS) International Symposium
Liver specific anti- cancer approach through microRNA-122 -regulated RNA replacement
P.06. Seoul, Korea. October. 31. 2011
(Won, R.H., Kim, J.H., Won, Y.S., Lee, S.-W.)

(114) The 3rd Korean Nucleic Acids Society (KNAS) International Symposium
Optimization of group I intron-based trans-splicing ribozyme for cancer therapy
P.09. Seoul, Korea. October. 31. 2011
(Im, J.Y., Kim, S.J., Lee, S.-W.)

(115) FoodMicro 2012
RNA aptamer-based simple assay for the detection of food pathogenic bacteria
P-197. Istanbul, Turkey. Sep. 4th, 2012.
(Maeng, J.-S., Kim, T. E., Park, B. H., Han, S. R., Lee, Y. J., Lee, S.-W., Kim, N.,Kim, C.-T., Kim, C.-J., Lee, M.-H., Cho, Y.-J.)

(116) 2012 International Meeting of the Federation of Korean Microbiological Societies
Development of an aptamer-based rapid and simple detection system for food pathogenic bacteria
No. 1011. Seoul, Korea. Oct. 12th, 2012.
(Park, B. H., Kim, T. E., Kwon, S., Han, S. R., Lee, Y. J., Kim, N., Kim, C.-T., Kim, C.-J., Lee, S.-W., Cho, Y.-J., and Maeng. J.-S.)

(117) Molecular Med TRI-CON 2013
RNA aptamer specific to the metastasis-inducing domain of carcinoambryonic antigen
San Francisco, USA. Feb. 13th-15th, 2013
(Lee, Y. J., Han, S. R., Lee, W. I., Jeong, J.-S., and Lee, S.-W.)

(118) A3RONA 2013 (Invited Speaker)
RNA aptamers for anti-viral therapeutics
Kobe, Japan. Aug. 30th-Sep. 1st, 2013
(Lee, S.-W.)

(119) Aptamers in Medicine and Perspectives (Invited Speaker)
RNA aptamers as intracellular decoys or molecular sensors for HCV therapeutics
Naples, Italy. Oct. 4th-Oct. 5th, 2013
(Lee, S.-W.)

(120) Aptamers in Medicine and Perspectives
Enhancement of chemosensitivity in colon cancer cells by RNA aptamer specific to carcinoembryonic antigen
No. 59. Naples, Italy. Oct. 4th-5th, 2013
(Lee, J.H., Jung, J.I., and Lee, S.-W.)

(121) Aptamers in Medicine and Perspectives
RNA aptamer as antiviral agent against Japanese Encephalitis Virus
No. 60. Naples, Italy. Oct. 4th-5th, 2013
(Han, S.R., and Lee, S.-W.)

(122) 9th Annual Meeting of the Oligonucleotide Therapeutics Society
In vitro selection of RNA aptamers which specifically bind to Japanese Encephalitis Virus Methyltransferase
No. 37. Naples, Italy. Oct. 6th-8th, 2013
(Han, S.R., and Lee, S.-W.)

(123) 9th Annual Meeting of the Oligonucleotide Therapeutics Society
Therapeutic application of carcinoembryonic antigen specific RNA aptamer in colon cancer
No. 65. Naples, Italy. Oct. 6th-8th, 2013
(Lee, J.H., Jung, J.I., and Lee, S.-W.)

(124) International Symposium on Hepatitis C Virus and Related Viruses
Inhibition of Hepatitis C Virus Replication Using HCV NS5B specific RNA aptamers
Melbourne, Austrailia. Oct. 6th-10th, 2013
(Lee, C.H., Lee, Y.J., Kim, J.H., Lim, J.H., Kim, J.H., Han, W., Lee, S.H., Noh, G.J., and Lee, S.W.)

(125) International Conference of the Korean Society for Molecular and Cellular Biology (Invited Speaker)
Overview of emerging technologies in nucleic acid-based therapetuics
Coex, Seoul, Korea. Oct. 9th-Oct. 11th, 2013
(Lee, S.-W.)

(126) The 18th Korea-Japan Cancer Research Workshop (Invited Speaker)
RNA-based therapeutics against hepatic metastasis of colon cancer
Gifu, Japan. Nov. 29th-Dec. 1st, 2013
(Lee, S.-W.)

(127) Keystone Symposia: RNA Silencing
Impaired maturation of primary microRNA by adenovirus VA RNA
No. 2018. Seattle, USA. Jan. 31st-Feb. 5th, 2014
(Kim, J. H., and Lee, C. H., and Lee, S.-W.)

(128) Keystone Symposia: RNA Silencing
Application of miRNA passenger strand with miRNA activity
No. 2019. Seattle, USA. Jan. 31st-Feb. 5th, 2014
(Kim, S. J., Yang, B., Park, Y. S., and Lee, S.-W.)

(129) The 2nd GRL International Symposium on Oligonucleotide Therapeutics (Invited Speaker)
RNA-based therapeutics against liver metastasis of colon cancer
SKKU, Suwon, Korea. Feb. 28th, 2014
(Lee, S.-W.)

(130) ENGII Conference on Inflammation (Invited Speaker)
RNA aptamers for therapeutics against hepatitis C virus
Suzhou, China. Mar. 13th-14th, 2014
(Lee, S.-W.)

(131) 2014 International Meeting of the Microbiological Society of Korea (Oral Presentation)
Inhibition of HCV replication with HCV NS5B specific RNA aptamer
Daegu, Korea. May 1st, 2014
(Lee, C. H., Kim, J. H., and Lee, S.-W.)

(132) 13th Osong International Bio Symposium International Co-symposium of KSGCT and ISPE
Adenoviral vector system for pri-miRNA delivery through VA RNA inhibition
No. P-04. C&V Center, Osong, Korea. Oct. 10th-11th, 2014
(Kim, J. H., Lee, C. H., and Lee, S.-W.)

(133) 13th Osong International Bio Symposium International Co-symposium of KSGCT and ISPE
Multiple use of RNA aptamers as intracellular decoys or molecular sensors for HCV therapeutics
No. P-05. C&V Center, Osong, Korea. Oct. 10th-11th, 2014
(Lee, C. H., Kim, J. H., and Lee, S.-W.)

(134) 13th Osong International Bio Symposium International Co-symposium of KSGCT and ISPE
Development of RNA aptamer specific to Japanese encephalitis virus methyltransferase as a therapeutic agent
No. P-07. C&V Center, Osong, Korea. Oct. 10th-11th, 2014
(Han S. R., and Lee, S.-W.)

(135) 13th Osong International Bio Symposium International Co-symposium of KSGCT and ISPE
Reduction of chemoresistance by carcinoembryonic antigen specific RNA aptamer in colon cancer
No. P-09. C&V Center, Osong, Korea. Oct. 10th-11th, 2014
(Lee, J. H., and Lee, S.-W.)

(136) 13th Osong International Bio Symposium International Co-symposium of KSGCT and ISPE
Development of regulated derivatives of group I-based trans-splicing ribozyme for cancer gene therapy
No. P-13. C&V Center, Osong, Korea. Oct. 10th-11th, 2014
(Yang, B., Kim, S.-J., Im, J. Y., Park, Y. S., Jeong, J.-S., and Lee, S.-W.)

(137) Asian 3 Roundtable on Nucleic Acids (A3RONA) 2014 (Invited Speaker)
RNA-based therapeutics against liver metastasis of colon cancer
Xiamen, China. Oct. 17th-18th, 2014
(Lee, S.-W.)

(138) Cell Symposia: Regulatory RNAs
Multifuctional RNA aptamers as intracellular decoys or molecular sensors for HCV therapeutics
Berkeley, CA, USA. Oct. 19th-21th
(Lee, C. H., Kim, J. H., and Lee, S.-W.)

(139) Cell Symposia: Regulatory RNAs
RNA aptamer specific to Japanese encephalitis virus methyltransferase as anti-viral agent
Berkeley, CA, USA. Oct. 19th-21th
(Han, S. R., and Lee, S.-W.)

(140) ESGCT and NVGCT Collaborative Congress
Developmet of cancer gene therapy based on cancer-specific RNA replacement through microRNA regulation
World Forum, Hague, Netherlands. Oct. 23th-26th, 2014
(Kim, J.-H., Jeong, J.-S., and Lee, S.-W.)

(141) ESGCT and NVGCT Collaborative Congress
Development of regulated derivatives of group I-based trans-splicing ribozyme for cancer gene therapy
World Forum, Hague, Netherlands. Oct. 23th-26th, 2014
(Yang, B., Kim, S. J., Im, J. Y., Park, Y. S., Jeong, J.-S., and Lee, S.-W.)

(142) ESGCT and NVGCT Collaborative Congress
Adenoviral vector system inhibiting VA RNA for pri-miRNA delivery
World Forum, Hague, Netherlands. Oct. 23th-26th, 2014
(Kim, J. H., Lee, C. H., and Lee, S.-W.)

(143) Keysotne Symposia: Precision Genome Engineering and Synthetic Biology
Conditional and target-specific transgene induction through RNA replacement using an allosteric trans-splicing ribozyme
No. 2050. Big Sky, Montana USA. Jan. 11th-16th,2015
(Kim, J., Jeong S., Kertsburg, A., Soukup, G. A., and Lee, S.-W.)

(144) 18th Annual Meeting of the American Society of Gene & Cell Therapy (Oral Presentation)
Targeted anticancer approach through microRNA-regulated Tumor-specific RNA replacement
No. 24. New Orleans, LA, USA. May 13th-16th, 2015
(Kim, J., Jeong, J.-S., and Lee, S.-W.)

(145) 18th Annual Meeting of the American Society of Gene & Cell Therapy
Controllable target-specific transgene induction using an allosteric trans-splicing ribozyme
No. 139. New Orleans, LA, USA. May 13th-16th, 2015
(Kim, J., Jeong, S., Kertsburg, A., Soukup, G. A., and Lee, S.-W.)

(146) KMB 2015 42nd Annual Meeting & International Symposium
Role of microRNAs in hepatitis C virus replication and related pathogenesis
S9. Gyeongju, Korea. Jun. 24th-26th, 2015
(Lee, S.-W.)

(147) Asian 3 Roundtable on Nucleic Acids (A3RONA) 2015 (Invited Speaker)
Targeted anticancer approach through microRNA-regulated tumor-specific RNA replacement
Suwon, Korea. Sep. 18th-20th, 2015
(Lee, S.-W.)

(148) The First A3 Roundtable Meeting on Chemical Probe Research Hub 2016 (Invited Speaker)
Group I Intron-based RNA Reprogramming for Cancer Theranostics
Fukuoka, Japan. Sep. 22nd-24th, 2016
(Lee, S.-W.)

(149) 24th Annual Congress of the European Society of Gene Therapy
Development of CTLA4-targetig trans-splicing ribozyme to deliver chimeric antigen receptor against tumor specific Tag72 antigen
P123, Florence, Italy, Oct. 18th-21st, 2016
(Lee, C. H., Han, S. R., and Lee, S.-W.)

(150) 24th Annual Congress of the European Society of Gene Therapy
Carcinoembryonic antigen specific RNA aptamer as a multifunctional cancer therapy device
P134, Florence, Italy, Oct. 18th-21st, 2016
(Lee, J. H., Jung, J. I.., and Lee, S.-W.)

(151) 24th Annual Congress of the European Society of Gene Therapy
Development of specific RNA aptamers against flavivirus methyltransferase
P148, Florence, Italy, Oct. 18th-21st, 2016
(Han, S. R. Jung, J. I.., and Lee, S.-W.)

(152) 24th Annual Congress of the European Society of Gene Therapy
Anti-miR-192 supresses progression of HCV-induced liver fibrosis through desensitization of hepatic stellate cells
P269, Florence, Italy, Oct. 18th-21st, 2016
(Kim, J. H., Lee, C. H., and Lee, S.-W.)

(153) 24th Annual Congress of the European Society of Gene Therapy
Optimization of RNA aptamer against the hepatitis C virus (HCV) NS5B protein improves anti-HCV efficacy and safety
P441, Florence, Italy, Oct. 18th-21st, 2016
(Lee, C. H., Kim, J. H., Han, S. R., and Lee, S.-W.)

(154) 24th Annual Congress of the European Society of Gene Therapy
Inhibition of hepatitis C virus replication through viral specific IFNA2 gene induction with to core-specific trans-splicing ribozyme
P457, Florence, Italy, Oct. 18th-21st, 2016
(Lee, C. H., and Lee, S.-W.)

(155) Asian 3 Roundtable on Nucleic Acids (A3RONA) 2017 (Invited Speaker)
Exosome-Mediated microRNA Transmission in HCV-Induced Liver Fibrosis.
Xi'an, China, Sep. 15th-17th, 2017
(Lee, S.-W.)

(156) Cell Symposia-CRISPR: From Biology to Technology and Novel Therapeutics
Gene replacement based on RNA reprogramming as an effective approach to cancer theranostics
Sitges, Spain, Oct. 22th-24th, 2017
(Lee, C. H., Han, S. R., Lee, J. H., Kim, J. H., Kim, T. H., Kim, Y.-H., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(157) 2017 Barcelona Conference on Epigenetics and Cancer
Gene replacement based on RNA reprogramming as an effective approach to cancer theranostics
Barcelona, Spain, Oct. 25th-26th, 2017
(Lee, C. H., Han, S. R., Lee, J. H., Kim, J. H., Kim, T. H., Kim, Y.-H., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(157) Molecular Med TRI-CON (Selected Oral presentation)
Targeted RNA replacement for personalized cancer therapeutics
San Francisco, CA, USA, Feb. 13th, 2018
(Lee, S.-W.)

(158) Molecular Med TRI-CON
Targeted RNA replacement for personalized cancer therapeutics
San Francisco, CA, USA, Feb. 12th-14th, 2018
(Lee, C. H., Han, S. R., Lee, J. H., Kim, J. H., Kim, T. H., Kim, Y.-H., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)


     
    국내학술회의발표
   

(1) The Korean Environmental Mutagen Society
Studies on replication process of the parvovirus KBSH in embryonic swine kidney cells. 1986.
(Lee, S.-W., Kim, Y.S., and Kang, H.S.)

(2) The 37th General Meeting of the Microbiological Society of Korea Spring 1997 (Oral Presentation)
Inhibition of HIV with intracellularly expressed RNA decoys. p. 53. Apr. 1997.
(Lee, S.-W.)

(3) The 9th Annual Meeting of the Korean Society for Molecular Biology (Oral Presentation)
In vitro selection of nuclease-resistant decoy RNAs that inhibit autoantibody functions. p. 169. Oct. 1997.
(Lee, S.-W.)

(4) The 234th Academy Research Meeting (Korea Science & Engineering Foundation) (Oral Presentation)
Development of in vitro selection of specific RNA ligands from oligonucleotide combinatorial library. Jun. 1998.
(Lee, S.-W.)

(5) The 4th Korean Hereditary Tumor Course (Oral Presentation)
Oligonucleotide Library. pp. 73-78. Aug. 1998.
(Lee, S.-W.)

(6) Workshop and symposium on Molecular diversity: Development and applications (Pohang Univ. of Sci. & Tech.) (Oral Presentation)
Development of specific ligands using oligonucleotide library. Sep. 1998.
(Lee, S.-W.)

(7) The 10th Annual Meeting of the Korean Society for Molecular Biology
Development of trans-splicing ribozyme for the gene therapy of genetic diseases. p. 355. Oct. 1998.
(Lee, S.-W., Sullenger, B. A.)

(8) The 10th Annual Meeting of the Korean Society for Molecular Biology
Isolation of high-affinity RNA ligands to HCV helicase from a random pool. p. 360. Oct. 1998.
(Hwang, B., Chung, K. M., Jang, S. K., and Lee, S.-W.)

(9) The 11th Annual Meeting of the Korean Society for Molecular Biology
Isolation of high-affinity RNA ligands to hnRNP L which is a cellular factor for HCV IRES-mediated translation. p. 176. Oct. 1999.
(Hwang, B., Hahm, B., Jang, S. K., and Lee, S.-W.)

(10) The 11th Annual Meeting of the Korean Society for Molecular Biology
In vitro selection of high-affinity RNA ;igands to NFAT from a random pool. p. 269. Oct. 1999.
(Bae, S., Oum, J.-H., Kim, J.-H., Park, J., and Lee, S.-W.)

(11) The 11th Annual Meeting of the Korean Society for Molecular Biology
Development and analysis of trans-splicing ribozymes to repair mutant transcripts which cause genetic diseases. p. 306. Oct. 1999.
(Jung, H.-S., and Lee, S.-W.)

(12) The 11th Annual Meeting of the Korean Society for Molecular Biology
Development of trans-splicing ribozyme targeted to the tumor suppressor gene. p. 307. Oct. 1999.
(Bae, S., Ryu, K.-J., Jeong, S., and Lee, S.-W.)

(13) The 11th Annual Meeting of the Korean Society for Molecular Biology
In vitro selection of potent RNA decoys that inhibit HCV RNA helicase. p. 314. Oct. 1999.
(Hwang, B., Chung, K. M., Jang, S. K., and Lee, S.-W.)

(14) The 11th Annual Meeting of the Korean Society for Molecular Biology
In vitro selected RNA aptamer specifically binds to sialyl lewis X sugar moiety and inhibits selectin/ligand adsorption of HL60 cells. p. 343. Oct. 1999.
(Um, T.-Y., Yu, J., Lee, S.-W., and Jeong, S.)

(15) The 3rd Symposium by Research Institute for Natural Science Dongguk University (Oral Presentation)
Development of RNA-based molecular therapeutics. P. 6. Nov. 1999.
(Lee, S.-W.)

(16) 8th Federation Meeting of Korean Basic Medical Scientists 2000
Molecular-genetic indices of gastric cancer. P. 123. Apr. 2000.
(Kimm, K., Lee, Y., Kim, J., Park, S., Jeong, M., Lee, S.-W., and Kim, S.)

(17) 2000 Spring Meeting and General Assembly of the Biochemical Society of the Republic of Korea (Oral Presentation)
Development of therapeutic or diagnostic agents using RNA aptamers selected in vitro. P. 64. May. 2000.
(Lee, S.-W.)

(18) 2000 Spring Meeting and General Assembly of the Biochemical Society of the Republic of Korea
In vitro selection of potent RNA inhibitors of NFAT. P. 198. May. 2000.
(Bae, S.-J., Oum, J.-H., Park, J., and Lee, S.-W.)

(19) The 12th Annual Meeting of the Korean Society for Molecular Biology
In vitro selection of high affinity RNA aptamers to HCV NS5B RNA-dependent RNA polymerase. p. 177. Oct. 2000.
(Lim, J., Myung, H., and Lee, S.-W.)

(20) The 12th Annual Meeting of the Korean Society for Molecular Biology
Development of trans-splicing ribozyme that specifically target and reprogram cancer specific telomerase. p. 221. Oct. 2000.
(Jung, H.-S., Kim, S.-C., Kimm, K., and Lee, S.-W.)

(21) The 12th Annual Meeting of the Korean Society for Molecular Biology
Development of trans-splicing ribozyme that specifically reprogram targeted HCV RNA. p. 312. Oct. 2000.
(Ryu, K.-J., Cho, J.-S., and Lee, S.-W.)

(22) The 12th Annual Meeting of the Korean Society for Molecular Biology
In vitro selected RNA aptamers as specific diagnostic agents for in situ detection of HCV NS3 proteins. The 12th Annual Meeting of the Korean Society for Molecular Biology. p. 312. Oct. 2000.
(Yeo, H., Jang, S., and Lee, S.-W.)

(23) 2001 Spring Scientific Meeting and General Assembly of the Biochemical Society of the Republic of Korea (Oral Presentation)
Ribozyme-mediated selective induction of new gene activities in specific cells by targeted trans-splicing. P. 96. May 2001.
(Lee, S.-W.)

(24) The 13th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Ribozyme-Mediated Induction of Wild-Type p53 Activity in Mutant p53-Related Cancer Cells. p. 201. Oct. 2001.
(Shin, K. S., Hwang, E.-S., and Lee, S.-W.)

(25) The 13th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Ribozyme-Mediated Selective Induction of Cytotoxin in Cancer Cells by Targeted Trans-Splicing. p. 202. Oct. 2001.
(Jung, H.-S., Kim, S.-C., Kwon, B.-S., Park, K. H., Chung, H. C., Kimm, K., and Lee, S.-W.)

(26) The 13th Annual Meeting of the Korean Society for Molecular and Cellular Biology
In Vitro Selection of Potent RNA Aptamers That Inhibit HCV NS5B RNA-Dependent RNA Polymerase. p. 278. Oct. 2001.
(Lim, J. H., Myung, H., and Lee, S.-W.)

(27) The 13th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Ribozyme-Mediated Selective Induction of New Gene Activities in HCV IRES-Expressing Cells by Targeted Trans-Splicing. p. 279. Oct. 2001.
(Ryu, K.-J., Cho, J.-S., Kim, J.-H., and Lee, S.-W.)

(28) The 13th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Development of Cancer Gene Therapy with Trans-Splicing Ribozyme Targeted to Cancer Specific Telomerase. p. 282. Oct. 2001.
(Kwon, B.-S., Jung, H.-S., and Lee, S.-W.)

(29) The 14th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Development of cancer gene therapy with trans-splicing ribozyme that specifically targets PD-ECGF transcripts. p. 252. Oct. 2002.
(Park, Y.-H., and Lee, S.-W.)

(30) The 14th Annual Meeting of the Korean Society for Molecular and Cellular Biology
High-affinity RNA aptamers of NFATp. p. 273. Oct. 2002.
(Cho, J.-S., Shin, K. S., Park, J., and Lee, S.-W.)

(31) The 14th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Selection RNA aptamers that act as both inhibitors and templates of HCV NS5B RNA-dependent RNA polymerase. p. 309. Oct. 2002.
(Lim, J. H., Myung, H., and Lee, S.-W.)

(32) The 14th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Development of cancer gene therapy with ribozyme that can induce cytotoxin specifically in cancer cells. p. 309. Oct. 2002.
(Kwon, B.-S., Jung, H.-S., Song, M.-S., Kim, S.-C., and Lee, S.-W.)

(33) RNA workshop 2003
Affinity chromatography using photolabile beads linked RNA aptamer in a chip: Hepatitis C virus (HCV) polymerase detection. [O12] Jul. 2003.
(Cho, S., Lee, S.-H., Chung, W.-J., Kim, Y.-K., Lee, Y.-S., Lee, S.-W., and Kim, B.-G.)

(34) RNA workshop 2003
A new role of ribozyme: Target specific induction of therapeutic new gene activity by trans-splicing. [O13] Jul. 2003.
(Jung, H.-S., Ryu, K.-J., Kim, J.-H., and Lee, S.-W.)

(35) RNA workshop 2003
Development of cancer gene therapy with trans-splicing ribozyme that can induce cytotoxin specifically in cancer cells. [P14] Jul. 2003.
(Kwon, B.-S., Jung, H.-S., Song, M.-S., and Lee, S.-W.)

(36) The 9th Hereditary Tumor and Genome Research Workshop 2003 (Oral Presentation)
Trans-splicing ribozyme for cancer gene therapy. PP. 59-75. Sep. 2003.
(Lee, S.-W.)

(40) 대한 생화학 분자생물학회 Genetic Modification Technology 연수강좌 2004 (Oral Presentation)
Trans-spicing ribozyme-mediated RNA relacement. PP. 9-20. Feb. 2004.
(이성욱)

(41) 동아대학교 암분자치료연구센터 심포지움: Recent trends in the development of target for cancer molecular therapy (Oral Presentation)
Trans-splicing ribozme as a new tool for cancer gene therapy. May. 2004.
(Lee, S.-W.)

(42) The 61st Annual Meeting 2004 of Korean Society for Biochemistry and Molecular Biology (Oral Presentation)
Tumor regression by trans-splicing ribozyme. P. 96. May 2004.
(Lee, S.-W.)

(43) The 61st Annual Meeting 2004 of Korean Society for Biochemistry and Molecular Biology
Modulation of hepatitis C virus replicon replication by specific RNA aptamers. P. 268. May 2004.
(Kim, J.-H., Kim, N. Y., Cho, S., Kim, B.-G., and Lee, S.-W.)

(44) The 61st Annual Meeting 2004 of Korean Society for Biochemistry and Molecular Biology
Specific cancer gene therapy with tissue-specific expression of targeted trans-splicing ribozyme. P. 277. May 2004.
(Song, M.-S., Kwon, B.-S., Jung, H.-S., Kim, A., Kim, I.-H., and Lee, S.-W.)

(45) The 61st Annual Meeting 2004 of Korean Society for Biochemistry and Molecular Biology
Trans-splicing ribozyme specifically targeted to hTERT as a specific modulator of cancer cell survival. P. 310. May 2004.
(Kwon, B.-S., and Lee, S.-W.)

(46) The 13th Korea Genome Organization Conference
Trans-splicing ribozyme as a functional modifier of specific message. P9-08. Aug 2004
(Kwon, B.-S., Jung, H.-S., Song, M.-S., Km, J. H., Won, Y. S., Kim, A., Kim, I.-H., and Lee, S.-W.)

(47) The 13th Korea Genome Organization Conference
RNA aptamers as specific and high-affinity ligands. P9-09. Aug 2004
(Lee, Y. J., Jeong, S., Kim, N. Y., Kim, J.-H., and Lee, S.-W.)

(48) 3rd IMT-2000 Review Workshop on 생물분자의 나노자기조립 기술개발 (Oral Presentation)
Characterization and application of in vitro selected RNA aptamers. pp 20-21. Sep 2004
(Lee, S.-W.)

(49) 2004 보건의료기술진흥사업 연구발표회
Development of specific cancer gene therapy via tissue-specific expression of selectively cytotoxin-inducing trans-splicing ribozyme. p214. Dec 2004
(Lee, S.-W.)

(50) The 62nd Annual Meeting 2005 of Korean Society for Biochemistry and Molecular Biology
RNA aptamer-mediated modulation of hepatitis C Virus replication. p336. May 2005
(Kim, J.-H., Lee, C. H., Kim, N. Y., and Lee, S.-W.)

(51) The 62nd Annual Meeting 2005 of Korean Society for Biochemistry and Molecular Biology
Efficacy of tumor-targeted trans-splicing ribozyme. p346. May 2005
(Kwon, B.-S., Kim, J. H., Won, Y. S., Jeong, J.-S., Kim, I.-H., and Lee, S.-W.)

(52) 제7기 생명과학최고 연구자 과정 (국립암센터)
Riboswitch. May. 2005
(Lee, S.-W.)

(53) The 13th Korea Genome Organization Conference
Trans-splicing ribozyme-mediated targeted and functional modification of specific transcript. p178. Sep 2005
(Kim, J. H., Kwon, B.-S., Jung, H.-S., Song, M.-S., Won, Y. S., Kim, A., Jeong, J.-S., Kim, I.-H., and Lee, S.-W.)

(54) The 13th Korea Genome Organization Conference
RNA aptamers as emerging specific ligands for proteomics analysis. p179. Sep 2005
(Lee, Y. J., Kim, N. Y., Jeong, S., and Lee, S.-W.)

(55) The 17th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Development of cancer gene therapy with trans-splicing ribozymes that reprogram cancer specific CKAP2 transcripts. p388. Oct 2005
(Kim, A., Song, M.-S., Ban, G., Lee, S.-W.)

(56) The 17th Annual Meeting of the Korean Society for Molecular and Cellular Biology
In vitro selection of high affinity RNA aptamers to prostate specific antigen. p389. Oct 2005
(Jeong, S., and Lee, S.-W.)

(57) The 17th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Development of trans-splicing ribozyme that specifically targets K-ras point mutated transcript. p389. Oct 2005
(Kim, J. H., Jang, S. Y., and Lee, S.-W.)

(59) The 17th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Identification of carcinoembryonic antigen specific aptamer. p389. Oct 2005
(Kim, N. Y., Lee, Y. J., Lim, J. H., Jung, H.-S. Jang, S. Y., and Lee, S.-W.)

(60) The 17th Annual Meeting of the Korean Society for Molecular and Cellular Biology
In vitro selection of RNA aptamers that specifically bind human Alpha-fetoprotein. p389. Oct 2005
(Lee, Y. J., Lim, J. H,. and Lee, S.-W.)

(61) The 17th Annual Meeting of the Korean Society for Molecular and Cellular Biology
New cancer gene therapy with trans-splicing ribozyme-mediated targeted replacement of hTERT RNA . p390. Oct 2005
(Kim, J. H., Kwon, B.-S., Jeong, J.-S., Kim, I.-H.,, and Lee, S.-W.)

(62) RNA Workshop 2006
RNA-based molecular medicine. p.18. Busan, Feb. 17th-18th, 2006
(Song, M.-S., and Lee, S.-W.)

(63) 2006 Annual Meeting and International Symposim of the Korean Society for Microbiology and Biotechnology
RNA-based specific cancer therapy via tissue-specific expression of selectively cytotoxin-inducing trans-splicing ribozyme. p405. Busan, Jun. 18th-20th, 2006
(Song, M.-S., Lee, J.-H., Kim, I.-H., and Lee, S.-W.)

(64) The 15th Korea Genome Organization Conference
RNA aptamers specific to metastasis-promoting domain of carcinoembryonic antigen. p140. Seoul, Sep. 21st-22nd, 2006
(Lee, Y. J., Kim, N. Y., Lim. J. H., and Lee, S.-W.)

(65) The 15th Korea Genome Organization Conference
Cancer gene therapy through trans-splicing ribozyme-mediated targeted and functional modification of hTERT transcript in a tissue-specific manner.p141. Seoul, Sep. 21st-22nd, 2006
(Jang, S. Y., Song, M.-S., Lee, J. H., Won, Y.-S., Kim, J. H., Kwon, B.-S., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(66) The 15th Korea Genome Organization Conference
Development of cancer gene therapy with trans-splicing ribozyme that can specifically replace K-RASV12 transcripts. p141. Seoul, Sep. 21st-22nd, 2006
(Kim, S. J., Jang, S. Y., Kim, J. H., and Lee, S.-W.)

(67) The 18th Annual Meeting of the Korean Society for Molecular and Cellular Biology (우수포스터상)
Hepatocarcinoma-selective cancer regression by liver-specific expression of targeted trans-splicing ribozyme. p381. Seoul, Oct. 12th-13th, 2006
(Song, M.-S., Lee, J.-H., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(68) The 18th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Cancer gene therapy by trans-splicing ribozyme-mediated targeted RNA replacement selectively in cancer cells. p382. Seoul, Oct. 12th-13th, 2006
(Won, Y.-S., Kwon, B.-S., Song, M.-S., and Lee, S.-W.)

(69) The 18th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Development of HCV-targeting hammerhead ribozyme which activity can be allosterically regulated by specific RNA aptamer. p382. Seoul, Oct. 12th-13th, 2006
(Lee, C. H., and Lee, S.-W.)

(70) The 18th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Selective retardation of cells expressing mouse CKAP2 transcript by targeted trans-splicing ribozyme. p382. Seoul, Oct. 12th-13th, 2006
(Ban, G., Kim, A., Song, M.-S., and Lee, S.-W.)

(71) The 18th Annual Meeting of the Korean Society for Molecular and Cellular Biology
High affinity RNA aptamers to active prostate specific antigen. p383. Seoul, Oct. 12th-13th, 2006
(Song, H. Y., Jeong, S., and Lee, S.-W.)

(72) The First General Meeting of Korean Society of Gene Therapy and Memorial Symposium
New gene therapeutic approach to hepatocarcinoma using trans-splicing ribozyme. p17. Seoul Coex, Dec. 1st, 2006
(Song, M.-S., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(73) The 99th National Meeting of the Korean Chemical Society (Oral Presentation)
RNA aptamers as emerging agents against hepatitis C virus replication. p92. Seoul Coex, Apr. 19th-20th, 2007
(Lee, S.-W.)

(74) 2007 대한 생화학 분자생물학회 춘계학술대회 및 기초의학학술대회 (Oral Presentation)
Trans-splicing ribozyme as emerging agent for cancer gene therapy. p21.
대전 건양대학교, Apr. 27th, 2007
(Lee, S.-W.)

(75) 제15회 기초의학학술대회
Anti-tumor effect and prolonged survival of cololectal liver metastasis with ribozyme-mediated cancer targeted gene therapy via systemic administration.
p238. 대전 건양대학교, Apr. 26th-27th, 2007
(Jeong, J.-S., Cho, K.-S., Kim, C.-O., Han, S.-Y., Lee, S.-W., and Kim, I.-H.)

(76) 제5회 내과학교실 연세의대 실험술기 Workshop "Cutting-edge Technology in RNA Interference" (Invited Speaker)
RNA replacement with trans-splicing ribozyme. pp.17-28.
연세대학교 의과대학. July 12th, 2007
(Lee, S.-W.)

(77) The 16th Korea Genome Organization Conference (Oral Presentation) (우수포스터상)
Liver cancer-specific targeting with PEPCK promoter-driven trans-splicing ribozyme. S10-2, E07
서울대학교, Sep. 13th-14th, 2007
(Song, M-.S., Lee, J.-H., Won, Y.-S., Kim, S. J., Jang, S. Y., Ban, G., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(78) The 16th Korea Genome Organization Conference (Oral Presentation)
Identification and characterization of RNA aptamers to metastasis-related domain of carcinoembryonic antigen. S10-3. C01
서울대학교, Sep. 13th-14th, 2007
(Lee, Y. J., Han, S. R., Lee, C. H., and Lee, S.-W.)

(79) 2007 International Meeting of the Federation of Korean Microbiological Societies (Invited Speaker)
Targeted RNA replacement by Tetrahymena group I intron. S15-2
교육문화회관, Oct 11th-12th, 2007
(Lee, S.-W.)

(80) The 19th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Cancer Gene Therapy by Trans-Splicing Ribozyme-Mediated Targeted RNA Replacement. M-13. Seoul Coex, Oct. 18th-19th, 2007
(Won, Y. S., Song, M.-S., Lee, J. H., Jang S. Y., Ban, G., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(81) The 19th Annual Meeting of the Korean Society for Molecular and Cellular Biology
In vitro selection and characterization of aptazyme Which Activity is Modulated by HCV Protein. O-23. Seoul Coex, Oct. 18th-19th, 2007
(Lee, C. H., and Lee, S.-W.)

(82) The 19th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Specific and efficient regression of hepatocarcinoma in vivo by Liver cancer-specific targeting with PEPCK promoter-driven trans-splicing ribozyme. O-24. Seoul Coex, Oct. 18th-19th, 2007
(Song, M.-S., Lee, J.-H., Won, Y.-S., Kim, S. J., Jang, S. Y., Ban, G., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(83) The 19th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Specific regression of cancer cells via RNA replacement by KRASV12 transcript-targeting trans-splicing ribozyme. O-30. Seoul Coex, Oct. 18th-19th, 2007
(Kim, S. J., Jang, S. Y., Song, M.-S., and Lee, S.-W.)

(84) The 19th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Development of theophylline-regulated trans-splicing ribozyme which targets hTERT RNA. O-31. Seoul Coex, Oct. 18th-19th, 2007
(Jang, S. Y., Kim, J. H., Soukup, G. A., and Lee, S.-W.)

(85) The 19th Annual Meeting of the Korean Society for Molecular and Cellular Biology
Development of RNA aptamers that can specifically bind to metastasis-related domain of carcinoembryonic antigen. O-32. Seoul Coex, Oct. 18th-19th, 2007
(Lee, Y. J., Han, S. R., and Lee, S.-W.)

(86) Korean Society of Gene Therapy's 1st Annual Meeting (Invited Speaker)
Exogenous control of targeted transgene expression with allosteric trans-splicing ribozyme. Seoul Coex, Nov. 30th, 2007
(Lee, S.-W.)

(87) Korean Society of Gene Therapy's 1st Annual Meeting
Gene therapy against liver cancer through hepatocarcinoma-specific targeting using PEPCK promoter-driven trans-splicing ribozyme. p40. Seoul Coex, Nov. 30th, 2007
(Song, M.-S., Lee, J.-H., Won, Y.-S., Kim, S. J., Jang, S. Y., Ban, G., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(88) Korean Society of Gene Therapy's 1st Annual Meeting
Cancer gene therapy through targeted RNA replacement using KRASV12 RNA-targeting trans-splicing ribozyme. p41. Seoul Coex, Nov. 30th, 2007
(Kim, S. J., Jang, S. Y., Song, M.-S., and Lee, S.-W.)

(89) Korean Society of Gene Therapy's 1st Annual Meeting (우수포스터상)
Development of hTERT-targeting and theophylline-regulated allosteric trans-splicing ribozyme. p46. Seoul Coex, Nov. 30th, 2007
(Jang, S. Y., Kim, J. H., Soukup, G. A., and Lee, S.-W.)

(90) Korean Society of Gene Therapy's 1st Annual Meeting
RNA aptamers against metastasis-related domain of CEA. p48. Seoul Coex, Nov. 30th, 2007
(Lee, Y. J., Han, S. R., and Lee, S.-W.)

(91) Korean Society of Gene Therapy's 1st Annual Meeting
Development of allosteric hammerhead ribozyme which activity is controlled by HCV NS5B protein. p49. Seoul Coex, Nov. 30th, 2007
(Lee, C. H., and Lee, S.-W.)

(92) 진단 및 치료제 개발을 위한 압타머 전문가 포럼 (Aptamer forum for diagnosis and therapeutics) (Invited Speaker)
RNA aptamers as anti-viral agents. Seoul 동국대학교, Dec. 26th, 2007
(Lee, S.-W.)

(93) RNA Workshop 2008
Selective regression of K-RASV12-expressing tumor tissues using trans-splicing ribozyme. p.28. Busan, July 10th-12th, 2008
(Kim, S. J., Jang, S. Y., Song, M.-S., Jeong, J.-S., and Lee, S.-W.)

(94) Korean Society of Gene Therapy's 2nd Annual Meeting.
Allosteric trans-splicing ribozyme as target-specific and exogenously controllable gene
therapeutic agent.
P-01. Seoul National University Children's Hospital, Seoul, Korea.
Nov. 28th, 2008
(Jang, S. Y. and Lee, S.-W.)

(95) Korean Society of Gene Therapy's 2nd Annual Meeting. (우수포스터상)
Isolation and characterization of RNA aptamers specific to JEV methyltransferase. P-02. Seoul National University Children's Hospital, Seoul, Korea.
Nov. 28th, 2008
(Han, S. R., Lee, Y. J., Oh, J.-W., and Lee, S.-W.)

(96) Korean Society of Gene Therapy's 2nd Annual Meeting.
Allosteric hammerhead ribozyme which activity can be specifically regulated by HCV
NS5B protein.
P-03. Seoul National University Children's Hospital, Seoul, Korea.
Nov. 28th, 2008
(Lee, C. H. and Lee, S.-W.)

(97) Korean Society of Gene Therapy's 2nd Annual Meeting.
Development of endogenously controllable RNA interference approach.
P-04. Seoul National University Children's Hospital, Seoul, Korea.
Nov. 28th, 2008
(Lee, J. H., Lee, C. H., and Lee, S.-W.)

(98) Korean Society of Gene Therapy's 2nd Annual Meeting.
Cancer gene therapy with K-RASV12 RNA-reprogramming trans-splicing ribozyme.
P-05. Seoul National University Children's Hospital, Seoul, Korea.
Nov. 28th, 2008
(Kim, S. J., Jeong, J.-S., and Lee, S.-W.)

(99) Korean Society of Gene Therapy's 2nd Annual Meeting.
Specific and efficient cancer gene therapeutic agent based on CKAP2 RNA-replacing
trans-splicing ribozyme.
P-06. Seoul National University Children's Hospital, Seoul, Korea.
Nov. 28th, 2008
(Ban, G., Kim, A., Song, M.-S., and Lee, S.-W.)

(100) Korean Society of Gene Therapy's 2nd Annual Meeting.
Trans-splicing ribozyme-based cancer gene therapy.
P-08. Seoul National University Children's Hospital, Seoul, Korea.
Nov. 28th, 2008
(Won, Y.-S. and Lee, S.-W.)

(101) Korean Society of Gene Therapy's 2nd Annual Meeting.
RNA aptamer as an efficient agent suppressing carcinoembryonic antigen inducing
hepatic metastasis of colon cancer.
P-20. Seoul National University Children's Hospital, Seoul, Korea.
Nov. 28th, 2008
P25-10. COEX, Seoul, Korea. Oct. 7-10, 2008
(Lee, Y. J., Han, S. R., Kim, M. J,, Jeong, J.-S., and Lee, S.-W.)

(102) RNA Workshop 2009 (Oral Presentation)
Trans-splicing ribozyme as theragnostic agent against cancer.
C-4. Yangyang, Korea. July 9th-11th, 2009
(Won, Y S., Kim, S. J., Ban, G., and Lee, S.-W.)

(103) The Korean Association of Immunobiologists, Immunlogy Training Course (Invited Speaker)
Trans-splicing ribozyme as cancer gene therapeutic agent
Cheonan, Korea. Aug. 21st-22nd, 2009
(Lee, S.-W.)

(104) K-OTS Workshop 2009 (Invited Speaker)
RNA aptamer that efficiently prevents intrahepatic metastasis of colon cancer.
Anmyeondo, Korea. Aug. 24th-25th, 2009
(Lee, S.-W.)

(105) K-OTS Workshop 2009 (Oral Presentation)
Trans-splicing ribozyme specifically reprogramming K-RASV12 transcript for cancer therapy.
Anmyeondo, Korea. Aug. 24th-25th, 2009
(Kim, S. J., Won, Y. S., Ban, G., Jeong, J.-S., and Lee, S.-W.)

(106) Korean Society of Gene Therapy's 3rd Annual Meeting.
Biological activity of microRNA passenger strand in microRNA function.
P-02. Seoul National University Children's Hospital, Seoul, Korea. Nov. 27th, 2009
(Kim, S. J., Won, Y. S., Lee, C. H., and Lee, S.-W.)

(107) Korean Society of Gene Therapy's 3rd Annual Meeting.
RNA-based cancer gene therapy with trans-splicing ribozyme which can expression can be specifically regulated by microRNA.
P-21. Seoul National University Children's Hospital, Seoul, Korea. Nov. 27th, 2009
(Won, Y. S., Kim, S. J., Lee, C. H., Kim, J. H., Won, R. H., and Lee, S.-W.)

(108) The 1st Winter Workshop of Korean Oligonucleotide Therapeutics Society (Invited Speaker)
Trans-splicing ribozyme for cancer therapy and molecular imaging.
Duksan, Korea. Feb. 8th-9th, 2010
(Lee, S.-W.)

(109) The 36th Annual Meeting of Korean Cancer Association (Invited Speaker)
RNA aptamer for cancer therapy and molecular imaging
S 5-4. Hotel Lotte, Seoul, Korea. June 10th-11th, 2010
(Lee, S.-W.)

(110) K-OTS Workshop 2010 (Oral Presentation)
Therapeutic potential of HCV NS5B protein specific RNA aptamer.
Incheon, Korea. Aug. 23rd-24th, 2010
(Lee, C. H., Han, W., Lee, S.-H., Lee, Y. J., Kim, J. H., Noh, G.-J., and Lee, S.-W.)

(111) The 22nd Annual Meeting of the Korean Society for Molecular and Cell Biology
Availability of miRNA passenger strand in miRNA pathway.
A-13. Coex, Korea. Oct. 7th-8th, 2010
(Kim S. J., Won, Y. S., Lee, C. H., and Lee, S.-W.)

(112) The 22nd Annual Meeting of the Korean Society for Molecular and Cell Biology
Development of RNA aptamers against Lin28 and Lin28B protein which inhibit let-7miRNA family processing.
A-14. Coex, Korea. Oct. 7th-8th, 2010
(Kim, M., Lee, Y. J., Han, S. R., Cho H., Lee, W., and Lee, S.-W.)

(113) The 22nd Annual Meeting of the Korean Society for Molecular and Cell Biology
Development of specific RNA aptamers to danofloxacin.
A-15. Coex, Korea. Oct. 7th-8th, 2010
(Han, S. R., Lee, Y. J., Lee, W. I., Cho, H., and Lee, S.-W.)

(114) The 22nd Annual Meeting of the Korean Society for Molecular and Cell Biology
Development of anti-viral RNA aptamer to Japanese encephalitis virus methytransferase.
A-16. Coex, Korea. Oct. 7th-8th, 2010
(Han S. R., Lee, Y. J., Kim, M. J., Lee, W. I., Cho, H., Lee, S.-W.)

(115) The 22nd Annual Meeting of the Korean Society for Molecular and Cell Biology
Inhibition of hepatitis C virus replication using HCV NS5B specific RNA aptamers.
A-17. Coex, Korea. Oct. 7th-8th, 2010
(Lee, C. H., Han, W., Lee, S.-H., Lee, Y. J., Kim, J., Noh, G.-J., and Lee, S.-W.)

(116) The 22nd Annual Meeting of the Korean Society for Molecular and Cell Biology
Cancer gene therapy based on the cancer-specific RNA replacement of through microRNA regulation.
B-47. Coex, Korea. Oct. 7th-8th, 2010
(Kim, J., Won, R., Won Y. S., Kim, S., Im, J.-Y., Ban, G., and Lee, S.-W. )

(118) The 22nd Annual Meeting of the Korean Society for Molecular and Cell Biology
Specific cancer cell regression with trans-splicing ribozyme which can be specifically regulated by microRNA.
A-48. Coex, Korea. Oct. 7th-8th, 2010
(Won, Y. S,, Kim, S. J., Lee, C. H., Kim, J. H., Won, R.-H., Im, J.-Y., and Lee, S.-W. )

(119) The 22nd Annual Meeting of the Korean Society for Molecular and Cell Biology
Development of allosteric hammerhead ribozyme which release HCV genome targeting siRNA.
M-12. Coex, Korea. Oct. 7th-8th, 2010
(Chang, B., Lee, C. H., Kim, H. W., and Lee, S.-W.)

(120) The 22nd Annual Meeting of the Korean Society for Molecular and Cell Biology
RNA aptamer as a therapeutic leads for cea-inducing hepatic metastasis.
A-32. Coex, Korea. Oct. 7th-8th, 2010
(Lee, Y. J., Han, S. R., Kim, M. J., Cho, H., Jeong, J.-S., and Lee, S.-W.)

(121) Korean Society of Gene and Cell Therapy's 4th Annual Meeting
Utility value of miRNA passenger strand in miRNA pathway.
P-05. Severance Hospital, Korea. Nov. 19th, 2010
(Kim, S. J., Won, Y. S., Lee, C. H., and Lee, S.-W.)

(122) Korean Society of Gene and Cell Therapy's 4th Annual Meeting
Development of cancer gene therapy based on the cancer-specific gene induction through microRNA regulation.
P-09. Severance Hospital, Korea. Nov. 19th, 2010
(Kim, J. H., Won, R., Won, Y. S., Kim, S., Im. J.-Y., Ban, G., and Lee, S.-W.)

(123) Korean Society of Gene and Cell Therapy's 4th Annual Meeting (우수포스터상)
Cancer gene therapy with regulated trans-splicing ribozyme by microRNA.
P-14. Severance Hospital, Korea. Nov. 19th, 2010
(Won, Y. S., Kim, S. J., Lee, C. H., Kim, J. H., Won, R. H., Im, J. Y., and Lee, S.-W.)

(124) Korean Society of Gene and Cell Therapy's 4th Annual Meeting
Therapeutic approach with allosteric ribozymes which release HCV genome targeting siRNA.
P-20. Severance Hospital, Korea. Nov. 19th, 2010
(Chang, B., Lee, C.-H., Kim, H.-W., and Lee, S.-W.)

(125) Korean Society of Gene and Cell Therapy's 4th Annual Meeting
Administration route for more efficacy and safety during HCC-selective gene therapy with adenovirus harboring cancer-targeting trans-splicing ribozyme and liver-specific promoters in vivo.
P-26. Severance Hospital, Korea. Nov. 19th, 2010
(Jeong, J.-S., Cho, K.-S., Han, S.-Y., Lee, S.-J., Lee, S.-W., and Kim, I.-H.)

(126) 한국산업식품공학회 2010년도 추계학술대회 (Invited Speaker)
앱타머 기반 식품위해요소 검출용 리간드 개발
Coex, Seoul, Korea. Nov. 26th, 2010.
(Lee, S.-W.)

(127) 5th Annual Meeting of Korean Society of Gene and Cell Therapy
Enhancement of efficacy of group I intron-based trans-splicing ribozyme for cancer therapy
P-11. Seoul, Korea. November. 25. 2011
(Im, J.Y., Kim, S.J., Lee, S.-W.)

(128) 5th Annual Meeting of Korean Society of Gene and Cell Therapy
Modulation of colon cancer through ectopic expression of miR-192
P-17. Seoul, Korea. November. 25. 2011
(Kim, J.H., Lee, C.H., Lee, S.-W.)

(129) 5th Annual Meeting of Korean Society of Gene and Cell Therapy
Anti- cancer approach based on the cancer-specific RNA replacement by microRNA regulation
P-19. Seoul, Korea. November. 25. 2011
(Kim, J.H., Won, Y.S., Won, R.H., Lee, S.-W.)

(130) 5th Annual Meeting of Korean Society of Gene and Cell Therapy
Hepatocarcinoma specific regression through microRNA-122 -regulated RNA replacement
P-34. Seoul, Korea. November. 25. 2011
(Won, R.H., Kim, J.H., Won, Y.S., Lee, S.-W.)

(131) 5th Annual Meeting of Korean Society of Gene and Cell Therapy
Inhibition of miR-122 functions specifically in HCV-replicating cells (Poster prize awardees)
O-1(Oral presentation). Seoul, Korea. November. 25. 2011
(Won, R.H., Kim, J.H., Won, Y.S., Lee, S.-W.)

(132) 한국분자세포생물학회 리보핵산분과 2013 RNA Summer Symposium
Specific and efficient cancer regression with trans-splicing ribozyme targeting KRAS(V12) RNA (Poster prize awardees)
P-8(Oral presentation). Busan, Korea. June. 24-25. 2013
(Kim, S.J., Kim, J.H., Yang, B., Jeong, J.S., Lee, S.-W.)

(133) 한국분자세포생물학회 리보핵산분과 2013 RNA Summer Symposium
Induction of chemosensitivity in 5-FU resistant cancer cells by CEA specific RNA aptamer
P-12. Busan, Korea. June. 24-25. 2013
(Lee, J.H., Lee, Y.J., Lee, S.-W.)

(134) 한국분자세포생물학회 리보핵산분과 2013 RNA Summer Symposium
In Vitro Selection of RNA aptamer specific to Japanese ENcephalitis Virus Methyltransferase
P-26. Busan, Korea. June. 24-25. 2013
(Han, S.R., Lee, Y.J., Kim, M.J., Lee, W.I., Lee, S.-W.)

(135) 2013 학연산 연구성과 교류회-한국유전자세포치료학회 워크샵 (Invited Speaker)
Aptamer as intramer or chemical decoy for HCV therapeutics
Seoul National University Children's Hospital, Seoul, Korea. Jun. 28th, 2013. (Lee, S.-W.)

(136) Korean Society of Gene and Cell Therapy's 7th Annual Meeting
Anti-tumor enhancement by modification of trans-splicing ribozyme
P-13. Seoul National University Dental Hospital, Seoul, Korea. Nov. 22nd, 2013
(Kim, S. J., Im, J. Y., Yang, B., Park, Y. S., and Lee, S.-W.)

(137) Korean Society of Gene and Cell Therapy's 7th Annual Meeting
CEA specific RNA aptamer-mediated chemoresistancy reduction and therapeutic application
P-14. Seoul National University Dental Hospital, Seoul, Korea. Nov. 22nd, 2013
(Lee, J. H., Jung, J. I., and Lee, S.-W.)

(138) Korean Society of Gene and Cell Therapy's 7th Annual Meeting
Development of RNA aptamer against JEV methyltransferase as antiviral agent
P-15. Seoul National University Dental Hospital, Seoul, Korea. Nov. 22nd, 2013
(Han, S. R., and Lee, S.-W.)

(139) Korean Society of Gene and Cell Therapy's 7th Annual Meeting (Oral presentation) (우수포스터상)
Inhibition of hepatitis C virus replication using RNA aptamer against HCV NS5B replicase
P-16. Seoul National University Dental Hospital, Seoul, Korea. Nov. 22nd, 2013
(Lee, C. H., Lee, Y. J., Kim, J. H., Lim, J. H., Kim, J.-H., Han, W., Lee, S.-H., Noh, G.-J., and Lee, S.-W.)

(140) 2015 한국핵산학회(KNAS) Summer Workshop (Invited Speaker)
Targted anticancer strategy through microRNA-regulated tumor-specific RNA replacement.
Hanwha Resort, Busan, Korea. Jun. 29th-30th, 2015
(Lee, S.-W.)

(141) 2015 한국핵산학회(KNAS) Summer Workshop
MIR-192 as potential target of HCV-induced liver fibrogenesis.
Hanwha Resort, Busan, Korea. Jun. 29th-30th, 2015
(Kim, J. H., Lee, C. H., and Lee, S.-W.)

(142) 2015 한국핵산학회(KNAS) Summer Workshop (우수포스터상)
Development of regulated derivatives of group I-based trans-splicing ribozyme for cancer gene therapy
Hanwha Resort, Busan, Korea. Jun. 29th-30th, 2015
(Yang, B., Kim, S. J., Im, J. Y., Park, Y. S., Jeong, J.-S., and Lee, S.-W.)

(143) 2015 한국핵산학회(KNAS) Summer Workshop
Carcinoembryonic antigen specific RNA aptamer as multimodal anticancer tools.
Hanwha Resort, Busan, Korea. Jun. 29th-30th, 2015
(Lee, J. H., Jung J. I., and Lee, S.-W.)

(144) 2015 한국핵산학회(KNAS) Summer Workshop
Development of specific RNA aptamer against Japanese encephalitis virus methyltransferase.
Hanwha Resort, Busan, Korea. Jun. 29th-30th, 2015
(Han, S., and Lee, S.-W.)

(145) 10th Annual Meeting of Korean Society of Gene and Cell Therapy (Oral presentation) (우수포스터상)
Specific delivery of anti-cancer siRNA via CEA aptamer-siRNA chimeras to CEA expressing cancer cells
O-4. Seoul National University Children's Hospital, Seoul, Korea. Nov. 27th, 2015
(Jung, J. I., Lee, C. H., Lee, Y. J., Won, Y.-S., and Lee, S.-W.)

(146) 10th Annual Meeting of Korean Society of Gene and Cell Therapy (우수포스터상)
Pharmacokinetics of a cholesterol-conjugated aptamer targeting the hepatitis C virus (HCV) NS5B protein
P-18. Seoul National University Children's Hospital, Seoul, Korea. Nov. 27th, 2015
(Lee, C. H., Lee, S.-H., Kim, J. H., Noh, Y.-H., Noh, G.-J., and Lee, S.-W.)

(147) 10th Annual Meeting of Korean Society of Gene and Cell Therapy
Hepatitis C virus induced IFNA2 gene inhibits viral replication by core-specific trans-splicing ribozyme
P-19. Seoul National University Children's Hospital, Seoul, Korea. Nov. 27th, 2015
(Lee, C. H., Kim, J. H., Kim, T., and Lee, S.-W.)

(148) 10th Annual Meeting of Korean Society of Gene and Cell Therapy (우수포스터상)
Efficient tumor regression through regulated derivatives of group I-based trans-splicing ribozyme
P-20. Seoul National University Children's Hospital, Seoul, Korea. Nov. 27th, 2015
(Han, S. R., Yang, B., Kim, S. J., Im, J. Y., Lee, W. S., Cho, M.-J., Jang, J.-H., Jeong, J.-S., and Lee, S.-W.)

(149) 10th Annual Meeting of Korean Society of Gene and Cell Therapy
Targeting miR-192 for the inhibition of HCV-induced liver fibrogenesis
P-21. Seoul National University Children's Hospital, Seoul, Korea. Nov. 27th, 2015
(Kim, J. H., Lee, C. H., and Lee, S.-W.)

(150) 10th Annual Meeting of Korean Society of Gene and Cell Therapy
Enhancement of anticancer chemosensitivity by carcinoembryonic antigen specific RNA aptamer
P-22. Seoul National University Children's Hospital, Seoul, Korea. Nov. 27th, 2015
(Lee, J. H., Lee, W. S., Jang, J.-H., Cho, M.-J., and Lee, S.-W.)

(151) 11th Annual Meeting of Korean Society of Gene and Cell Therapy (Oral presentation) (우수포스터상)
Tetrahymena thermophilia group I intron-based RNA reprogramming as an effective approach to cancer theranostics
O-3. Seoul National University Children's Hospital, Seoul, Korea. Dec. 5th, 2016
(Han, S. R., Kim, J., Kim, Y.-H., Jeong, J. S., Kim, I.-H., and Lee, S.-W.)

(152) 11th Annual Meeting of Korean Society of Gene and Cell Therapy
Hepatitis C virus specific induction of IFNA2 gene to inhibit viral replication by core region targeted trans-splicing ribozyme
P-10, Seoul National University Children's Hospital, Seoul, Korea. Dec. 5th, 2016
(Lee, C. H., and Lee, S.-W.)

(153) 11th Annual Meeting of Korean Society of Gene and Cell Therapy (우수포스터상)
Improvement of anti-viral effectiveness through optimization of RNA aptamer against the hepatitis C virus NS5B protein
P-11, Seoul National University Children's Hospital, Seoul, Korea. Dec. 5th, 2016
(Lee, C. H., Kim, J. H., Han, S. R., and Lee, S.-W.)

(154) 11th Annual Meeting of Korean Society of Gene and Cell Therapy
Development of CTLA4-targetig trans-splicing ribozyme to deliver tumor specific antigen targeting chimeric antigen receptor
P-12, Seoul National University Children's Hospital, Seoul, Korea. Dec. 5th, 2016
(Lee, C. H., Han, S. R., and Lee, S.-W.)

(155) 11th Annual Meeting of Korean Society of Gene and Cell Therapy
Anti-miR-192 represses progression of HCV-induced liver fibrosis through deactivation of hepatic stellate cells
P-13, Seoul National University Children's Hospital, Seoul, Korea. Dec. 5th, 2016
(Kim, J. H., Lee, C. H., and Lee, S.-W.)

(156) 11th Annual Meeting of Korean Society of Gene and Cell Therapy
Carcinoembryonic antigen specific RNA aptamer as a multifunctional cancer therapeutic tool
P-16, Seoul National University Children's Hospital, Seoul, Korea. Dec. 5th, 2016
(Lee, J. H., Jung, J. I., and Lee, S.-W.)

(157) 11th Annual Meeting of Korean Society of Gene and Cell Therapy
Development of specific RNA aptamers to flavivirus methyltransferase as therapeutic agent
P-19, Seoul National University Children's Hospital, Seoul, Korea. Dec. 5th, 2016
(Han, S. R., Jung, J. I., and Lee, S.-W.)

(158) 12th Annual Meeting of Korean Society of Gene and Cell Therapy (Oral presentation) (우수포스터상)
Down-regulation of exosomal miRNAs represses HCV-induced liver fibrosis through deactivation of hepatic stellate cells
O-2, Bexco, Busan, Korea. Nov. 3th-4th, 2017
(Kim, J. H., Lee, C. H., and Lee, S.-W.)

(159) 12th Annual Meeting of Korean Society of Gene and Cell Therapy
Enhanced therapeutic effect of hTERT targeting trans-splicing ribozyme and radiation therapy for liver cancer
P-20, Bexco, Busan, Korea. Nov. 3th-4th, 2017
(Lee, C. H., Choi, C., Shin, S.-W., Park, H. C., Han, Y., and Lee, S.-W.)

(160) 12th Annual Meeting of Korean Society of Gene and Cell Therapy
Multifunction of Carcinoembryonic Antigen specific RNA aptamer as a cancer therapeutic tool
P-21, Bexco, Busan, Korea. Nov. 3th-4th, 2017
(Lee, J. H., Jung, J. I., and Lee, S.-W.)

(161) 12th Annual Meeting of Korean Society of Gene and Cell Therapy
In vitro selection of RNA aptamers against dengue virus methyltransferase as anti-DENV agent
P-26, Bexco, Busan, Korea. Nov. 3th-4th, 2017
(Han, S. R., Jung, J. I., and Lee, S.-W.)


     
  연구수행과제
   

1997년 6월-1998년 5월
‘97 유전공학연구 (과제번호; GE-97-210),
교육부 학술진흥재단 (과제명: 유전병의 유전자치료를 위한 trans-splicing ribozyme의 개발)

1998년 3월-2000년 2월
‘98 핵심전문연구 (과제번호; 981-0507-036-2),
한국과학재단 (과제명: 자가면역 질병환자의 자가항체반응을 억제하는 RNA 분자의 분리 및 분석)

1998년 5월-2001년 4월
보건의료기술연구개발사업 (과제번호; HMP-98-B-3-0020), 보건복지부
(과제명: C형 간염바이러스 유전자의 발현과 발현된 유전자 산물의 기능을 억제하는 RNA 분자의 탐색 및 생산을 통한 HCV 감염질환에 대한 치료방법 연구 - 유용 aptamer들의 생산 및 특성 연구)

1998년 12월-1999년 11월
과학기술기초중점연구지원 (과제번호; 1998-019-F00026), 학술진흥재단
(과제명: 돌연변이 유전자 전사체를 보정할 수 있는 trans-splicing ribozyme을 이용한 유전자 치료법 개발 - 유전질환을 유발하는 돌연변이 유전자 전사체를 보정할 수 있는 trans-splicing ribozyme의 개발 및 분석)

1999년 10월-2002년 10월
‘99년 암정복추진연구개발사업, 보건복지부
(과제명: 위암 백신 개발의 기초 연구 - Dendritic cell-based tumor vaccines에 의한 암 특이적 면역 유도 반응 및 확인)

1999년 12월-2001년 11월
‘99 학술진흥기반사업 선도연구자지원 (과제번호; KRF-99-041-D00408), 학술진흥재단
(과제명: 표적유전자 전사체의 재프로그램을 유발하는 trans-splicing ribozyme을 이용한 C형 간염바이러스 감염질환에 대한 유전자 치료법 개발)

2000년 9월-2001년 8월
기초과학연구지원사업 (과제번호; DP0412), 학술진흥재단
(과제명: 전사조절인사 NFAT의 활성화 및 NFAT 기능억제에 의한 면역반응의 조절연구)

2000년 9월-2003년 8월
목적기초연구 (과제번호; R01-2000-000-00147-0), 과학재단
(과제명: 남성불임자 Rbm의 기능연구)

2001년 6월-2004년 5월
기초과학연구지원사업 (과제번호; DP0572), 학술진흥재단
(과제명; Telomerase 유전자 전사체를 특이적으로 치환하는 trans-splicing ribozyme 개발을 통한 암 유전자 치료법 연구)

2001년 12월-2003년 11월
IMT-2000 출연금 기술개발 지원사업 (과제번호; 01-PJ11-PG9-01BT00B-0012), 보건복지부
(과제명; 단백질과의 결합을 고려한 RNA 구조 예측 및 이를 이용한 신약 탐색 - 단백질과 결합하는 RNA aptamer의 구조 및 기능 연구를 통한 단백질 억제제 탐색)

2001년 12월-2004년 11월
IMT-2000 출연금 기술개발 지원사업 (과제번호; IMT2000-B3-2), 과학기술부
(과제명; 생물분자의 나노자기조립 기술개발 - 나노입자복합체를 이용한 분자인식체 개발)

2003년 7월-2005년 5월
보건의료기술연구개발사업
(과제번호; 03-PJ1-PG3-21000-0008), 보건복지부 (연구비; 60,000 천원)
(과제명; 선택적으로 세포사 활성을 유도하는 trans-splicing ribozyme의 조직 특이적 발현을 통한 특이적 암 유전자치료법 연구)

2003년 7월-2006년 3월
21C 프론티어연구개발사업, 지능형 마이크로시스템 개발사업 (과제번호; MS-04-211), 과학기술부
(과제명; 마이크로 비드를 이용한 단백질 농축 및 진단시스템 개발)

2004년 8월-2007년 6월
‘04년 암정복추진연구개발사업, 보건복지부
(과제명: 새로운 세포주기조절유전자를 이용한 한국인 호발암 치료법 개발 - CKAP2 RNA의 특이적 표적 및 치환을 통한 종양 치료법 개발)

2004년 9월-2007년 8월
2004년도 기초연구지원(특정기초) 사업 (과제번호; R01-2004-000-10436-0), 과학기술부 한국과학재단
(과제명: 돌연변이 Ras RNA의 특이적 치환을 통한 암유전자 치료법 개발)

2004년 12월-2005년 11월
2004년도 선도연구자 지원사업 (과제번호; KRF-2004-041-C00296), 학술진흥재단
(과제명; C형 간염바이러스 (HCV) 조절단백질에 의해 그 활성이 조절되는 HCV 게놈 표적 hammerhead 리보자임 개발)

2005년 4월-2008년 3월
특정연구개발과제 (유전자치료기술사업)(과제번호; 2005-01056) 과학기술부 한국과학재단
(과제명; Allosteric trans-splicing ribozyme의 개발을 통한 표적 특이적이며 조절 가능한 유전자 치료기술 연구)

2005년 12월-2006년 11월
2005년도 선도연구자 지원사업 (과제번호; KRF-2005-041-C00340) 학술진흥재단
(과제명; C형 간염바이러스 게놈을 특이적으로 변형할 수 있는 trans-splicing aptazyme 개발

2005년 12월-2006년 11월
서울시 전략산업 혁신 클러스터 육성 지원사업
(과제명;리간드 라이브러리를 이용한 신기능 나노 바이오 소재의 개발)

2006년 2월-2007년 11월
Aptamer Initiative 연구사업단 전략/혁신과제
포항공과대학 생명공학센터 (위탁책임자)
(과제명;암태아성 항원에 의한 암전이를 억제할 수 있는 RNA 앱타머 개발)

2006년 4월-20010년 3월
21C 프론티어연구개발사업, 지능형 마이크로시스템 개발사업 (3단계)
산업자원부 (공동연구원)
(과제명;Bead affinity chromatography(BAC)를 이용한 고성능 샘플 전처리 기능칩 개발)

2006년 11월-2007년 7월
질병관리본부 연구용역사업
질병관리본부 (공동연구원)
(과제명;Aptamer를 이용한 사스바이러스 진단 신기술 개발)

2007년 1월-2007년 12월
한국식품연구원 용역사업
위탁과제 책임
(과제명;식품위해요소 검출용 앱타머기술 개발)

2007년 5월-2008년 5월; 암정복추진연구개발사업
이행성암연구특별프로그램
보건복지부 (세부책임자)
(과제명;조직 특이적 프로모터와 암세포 표적 trans-splicing ribozyme를 가진 다기능 암유전자 치료용 아데노바이러스의 개발 - 간암세포 특이적으로 hTERT RNA를 치환하여 치료용유전자 발현을 유도할 수 있는 trans-splicing ribozyme의 개발 및 최적화)

2007년 8월-2008년 7월; 2007년도 기초연구과제 (기초과학분야) 지원사업 (공동연구)
(과제번호; KRF-2007--C00211)
학술진흥재단 (연구책임자)
(과제명;MicroRNA 발현 조절을 통한 C형 간염바이러스 증식 억제 연구)

2008년 4월-2011년 3월; 미래기반기술개발사업 (유전자치료 및 손상복구 연구사업, 2단계)
(과제번호; 2009-0065408)
교육과학기술부 한국과학재단 (연구책임자)
(과제명;Allosteric trans-splicing ribozyme의 개발을 통한 표적 특이적이며 조절 가능한 유전자 치료기술 연구)

2008년 2월-2008년 11월; Aptamer Initiative 연구사업단 전략/혁신과제
포항공과대학 생명공학센터
POSTECH (연구책임자)
(과제명;RNA aptamer에 의한 암태아성 항원 유도성 암전이 제어 연구)

2008년 4월-2011년 3월;차세대 핵심환경개발기술사업
환경부 (공동연구원)
(과제명; 나노기반의 압타머 활용기술을 통한 위해성 평가 시스템 개발)

2008년 5월-2010년 3월; 보건의료기술연구개발사업
단독중개연구
(과제번호; A080173)
보건복지가족부 (연구책임자)
(과제명; Aptazyme기반RNA간섭조절을통한C형간염바이러스증식억제연구)

2008년 11월-2009월 10월; 2008년도 기초연구과제 지원사업 (단독연구)
(과제번호; KRF-2008-313-C00668)
학술진흥재단 (연구책임자)
(과제명; antimiR의 선택적 활성화를 통한 C형 간염바이러스 복제 억제 및 그 기전연구.
Studies on the inhibition of hepatitis C virus replication with selective antimiR-activation and its mechanism)

2008년 11월-2010년 10월; 보건의료기술연구개발사업
단독중개연구
(과제번호; A084076)
보건복지가족부 (연구책임자)
(과제명; hybridRNA기반암세포특이적siRNA전달체개발연구.
StudiesonthedevelopmentofhybridRNA-basedcancer-specificsiRNAdeliverysystem)

2008년 12월-2011년 9월; 전략기술개발사업
한국산업기술평가원
지식경제부 (위탁책임자)
(과제명; 세포 특이적 압타머 선별 기법 개발을 통한 고성능 암진단용 압타머 컨텐츠 발굴)

2008년 12월-2011월 11월; 국제기술협력사업/한미공동기술개발사업
한국산업기술재단 (Grant No. KT-2008-NT-APFS0-0001)
(과제명; Human T cell specific RNAi-based therapetic nano-medicine for AIDS)

2009년 9월-2012년 8월; 일반연구자지원사업(기본연구:협동)
(과제번호; 2009-0086239)
교육과학기술부 (연구책임자)
(과제명; 마이크로 RNA 조절을 통한 암특이적 RNA 치환 기반 암 유전자 치료 기술 연구)

2010년 10월-2015년 3월; 바이오의료기기산업원천기술개발사업 (참여)
(과제번호; 10035159)
지식경제부 (참여기관 책임자)
(과제명; 핵산조절기술을 이용한 항바이러스 핵산치료제 개발)

2010년 7월-2012년 5월; 보건의료기술연구개발사업
단독중개연구
(과제번호; A100399)
보건복지가족부 (연구책임자)
(과제명; Chimeric RNA bi-aptamer 기반 C형 간염바이러스 증식억제 연구. Inhibition of hepatitis C virus replication with chimeric RNA bi-aptamer)

2010년 10월-2015년 3월; 바이오의료기기산업원천기술개발사업 (참여)
(과제번호; 10035159)
지식경제부 (참여기관 책임자)
(과제명; 핵산조절기술을 이용한 항바이러스 핵산치료제 개발)

2011년 4월-2014년 3월; 차세대 신약기반 기술개발사업 (3단계)
(과제번호; 2011-0002169)
교육과학기술부 한국연구재단 (NRF; National Research Foundation (공동연구원)
(과제명; 바이러스벡터를 이용한 항암 유전자치료 기술개발)

2012년 9월-2015년 8월; 일반연구자지원사업(기본연구:추가지원)
(과제번호; 2012R1A1A2A10039116)
교육과학기술부 (연구책임자)
(과제명; 마이크로 RNA 조절을 통한 암특이적 RNA 치환 기반 암유전자 치료 기술 연구)

2012년 12월-2017년 11월; 원천기술개발사업 - 바이오의료기술개발 사업 - 차세대응용오믹스사업
(과제번호; 2012M3A9B6055197 - 2012M3A9B6055200)
미래창조과학부 한국연구재단 (총괄책임자)
(과제명; 유전자 전달체 표적화기술 개발 - 유전자 전사 및 전사 후 자가 조절 표적화 유전자 치료기술 개발)

2013년 6월-2016년 5월; 중견연구자지원사업 (핵심연구:개인)
(과제번호; 2013R1A2A2A01004649)
미래창조과학부 (연구책임자)
(과제명; C형 간염바이러스 감염에 의한 microRNA 매개 간섬유화와 바이러스 복제 기전 네트워크 및 억제 연구)

2015년 9월-2018년 8월; 원천기술개발사업 - 바이오의료기술개발 사업 - 차세대신약 기반기술개발사업
미래창조과학부 (공동연구원)
(과제명; 난치성 암치료를 위한 지능형 복제가능 레트로바이러스벡터 최적화)

2015년 11월-2017년 10월; 중견연구자지원사업 (도약연구; 성과확산)
(과제번호; 2015R1A2A1A15054252)
미래창조과학부 (연구책임자)
(과제명; 간암세포 특이적 RNA 치환 유도 라이보자임 기반 진행성 간암 유전자치료제 개발)

2017년 3월-2020년 2월; 기초연구사업 (중견연구사업)
(과제번호; 2017R1A2B2003368)
과학기술정보통신부 (연구책입자)
(과제명; TERT promoter mutation 특이 표적 후성편집 기반 암 제어 및 그 기전 연구)

2017년 4월-2022년 3월; 원천기술개발사업 - 바이오의료기술개발 사업 - 신약개발 파이프라인관리사업
(과제번호; 2017M3A9C8031781)
과학기술정보통신부 (공동연구원)
(과제명; 텔로머라제 특이 표적 치환 바이러스 벡터 기반 간암 유전자치료제 개발)

 

   
  수상사항
   

2004년 11월;2004년 보건의료기술진흥사업 우수연구사례 선정 (이성욱)
선택적으로 세포사 활성을 유도하는 trans-splicing ribozyme의 조직특이적 발현을 통한 특이적 암 유전자치료법 연구

2005년 2월; 범정 학술상 (최우수석사 졸업 논문상) (권병수)
단국대학교
"Development of cancer gene therapy with trans-splicing ribozyme that reprogram cancer specific hTERT transcripts"

2005년 9월;무수포스터상 (김주현)
The 14th Korea Genome Organization Conference
“Trans-splicing ribozyme-mediated targeted and functional modification of specific transcript”

2005년 10월;우수포스터상 (이영주, 임종훈, 이성욱)
2005년도 한국분자세포생물학회 추계학술대회
"In vitro selection of RNA aptamers that specifically bind human alpha-fetoprotein"

2006년 6월; 우수포스터상 (송민선, 이주한, 김인후, 이성욱)
2006 Annual Meeting and International Symposim of the Korean Society for Microbiology and Biotechnology
"RNA-based specific cancer therapy via tissue-specific expression of selectively cytotoxin-inducing trans-splicing ribozyme"

2006년 8월;학술진흥재단 생명과학 분야 우수과제 선정 (이성욱)
Lan, N., Howrey, R., Lee, S.-W., Smith, C., and Sullenger, B. (1998). Ribozyme-mediated repair of sickle β-globin mRNAs in erythrocyte precursors. Science 280: 1593-1596.

2006년 10월;우수포스터상 (송민선)
The 18th Annual Meeting of the Korean Society for Molecular and Cellular Biology
“Hepatocarcinoma-selective cancer regression by liver-specific expression of targeted trans-splicing ribozyme”

2007년 9월;우수포스터상 (송민선)
The 16th Korea Genome Organization Conference
Liver cancer-specific targeting with PEPCK promoter-driven trans-splicing ribozyme

2007년 11월; 범은학술상 (연구업적부문) (이성욱)
단국대학교

2007년 11월; 우수포스터상 (장선영, 김주현, Soukup, GA., 이성욱)
Korean Society of Gene Therapy's 1st Annual Meeting
Development of hTERT-targeting and theophylline-regulated allosteric trans-splicing ribozyme

2008년 2월; 범정 학술상 (우수박사 졸업 논문상) (송민선)
단국대학교
“Development of tissue-specific promoter driven tumor-targeting trans-splicing ribozyme system as a multifunctional cancer gene therapy device in vivo”

2008년 11월; 우수포스터상 (한승렬, 이영주, 오종원, 이성욱)
Korean Society of Gene Therapy's 2nd Annual Meeting
Isolation and characterization of RNA aptamers specific to JEV methyltransferase.

2008년 2월; 범정 학술상 (우수석사 졸업 논문상) (반가이)
단국대학교
“Development of target specific trans-splicing ribozymes which activity can be selectively induced by tissue-specific promoter or micro-RNA”

2009년 11월; 우수포스터상 (이창호)
The 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium Vector-based antimiR expression system which inhibits miRNA function

2009년 11월; 우수포스터상 (이영주)
The 1st Korean Oligonucleotide Therapeutics Society International Symposium : Aptamers and RNAi Therapeutics RNA aptamer as a potent inhibitor against hepatic metastasis of colon cancer.

2010년 11월 19일; 우수포스터상 (원유섭, 김성진, 이창호, 김주현, 원란희, 임지영, 이성욱)
Korean Society of Gene and Cell Therapy's 4th Annual Meeting Cancer gene therapy with regulated trans-splicing ribozyme by microRNA.

2011년 6월; 우수포스터상 (이창호,김지현,김희원, 이성욱)
The 16th Annual Meeting of the RNA Society and The 13th Annual Meeting of the RNA Society of Japan
Allosteric ribozyme capable of specifically inhibiting miR-122 functions only in HCV replicating cells.

2011년 9월; Student Travel Grant (이창호,김지현,김희원, 이성욱)
7th Annual Meeting of the Oligonucleotide Therapeutics Society
ALLOSTERIC RIBOZYME CAPABLE OF SPECIFICALLY INHIBITING MIR-122 FUNCTIONS THROUGH HCV NS5B PROTEIN SENSING.

2011년 10월; 우수포스터상(이창호,김지현,김희원, 이성욱)
The 23rd Annual Meeting of the Korean Society for Molecular and Cellular Biology
Genetic system inhibiting miR-122 function specifically in HCV-replicating cells.

2011년 11월; 우수포스터상 / 구두발표(이창호,김지현,김희원, 이성욱)
5th Annual Meeting of Korean Society of Gene and Cell Therapy
Inhibition of miR-122 functions specifically in HCV-replicating cells.

2012년 7월; 우수포스터상(이영주, 한승렬, 이원일, 정진숙, 이성욱)
2012 한국핵산학회(KNAS)-RNA 연구회(리보핵산분과) Joint Summer Workshop
RNA aptamer targeting carcinoembryonic antigen prevents hepatic metastasis of colon cancer cells.

2012년 10월; Best Achievements in Bio-Medical Technology Development Program of NRF
2012 Korean Society for Molecular and Cellular Biology Annual Meeting
RNA-based gene therapeutic agents against hepatic metastasis of colon cancer

2012년 10월; 우수박사학위논문상(이영주, 한승렬, 이원일, 정진숙, 이성욱)
2012 Korean Society for Molecular and Cellular Biology Annual Meeting
RNA aptamer targeting carcinoembryonic antigen prevents hepatic metastasis of colon cancer cells in mice

2012년 11월; 범은학술상 (특별상)(이성욱)
단국대학교

2012년 11월; Tae Gwan Park Award(한승렬, 이영주, 이원일, 이성욱)
The 4th Korean Nucleic Acids Society International Symposium
Development of RNA aptamers against food-borne pathogen bacteria

2012년 11월; 우수포스터상(김주현, 원란희, 이성욱)
Korean Society of Gene and Cell Therapy's 6th Annual Meeting
Anti-cancer therapy based on the cancer-specific gene induction by microRNA regulation

2013년 6월; 우수포스터상(김성진, 김주현, 양빛나, 정진숙, 이성욱)
2013 RNA Summer Symposium
Specific and efficient cancer regression with tran-splicing ribozyme targeting KRASV12 RNA

2013년 10월; 2013 기초연구 우수성과 50선 (이성욱)
한국연구재단
대장암 간전이 억제제 '핵산 앱타머' 개발

2013년 11월; 우수포스터상(이창호, 이영주, 김지현, 한원교, 이주한, 노규정, 이성욱)
Korean Society of Gene and Cell Therapy's 7th Annual Meeting
Inhibition of hepatitis C virus replication using RNA aptamer against HCV NS5B replicase

2014년 10월; 우수포스터상(이창호, 김지현, 이성욱)
13th Osong International Bio Symposium International Co-symposium of KSGCT and ISPE
Multiple use of RNA aptamers as intracellular decoys or molecular sensors for HCV therapeutics

2014년 11월; 범은학술상(산학협력부문) (이성욱)
단국대학교

2015년 6월 30일; 우수포스터상(양빛나, 김성진, 임지영, 박영숙, 정진숙, 이성욱)
2015 한국핵산학회(KNAS) Summer Workshop
Development of regulated derivatives of group I-based trans-splicing ribozyme for cancer gene therapy

2015년 11월 27일; 우수포스터상(정재인, 이창호, 이영주, 원유섭, 이성욱)
10th Annual Meeting of Korean Society of Gene and Cell Therapy
Specific delivery of anti-cancer siRNA via CEA aptamer-siRNA chimeras to CEA expressing cancer cells

2015년 11월 27일; 우수포스터상(이창호, 이수한, 김지현, 노욱한, 노규정, 이성욱)
10th Annual Meeting of Korean Society of Gene and Cell Therapy
Pharmacokinetics of a cholesterol-conjugated aptamer targeting the hepatitis C virus (HCV) NS5B protein

2015년 11월 27일; 우수포스터상(한승렬, 양빛나, 김성진, 임지영, 이원석, 조민지, 장지현, 정진숙, 이성욱)
10th Annual Meeting of Korean Society of Gene and Cell Therapy
Efficient tumor regression through regulated derivatives of group I-based trans-splicing ribozyme

2015년 12월 22일; 보건복지부 장관 표창(이성욱)
2015년 보건의료기술진흥 유공자 정부포상
보건복지부

2015년 12월; 2015년 보건의료 R&D 우수성과 사례 20선 선정(이성욱)
보건복지부 보건산업진흥원
An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice

2016년 12월 5일; 우수포스터상(한승렬, 김주현, 김윤희, 정진숙, 김인후, 이성욱)
11th Annual Meeting of Korean Society of Gene and Cell Therapy
Tetrahymena thermophilia group I intron-based RNA reprogramming as an effective approach to cancer theranostics

2016년 12월 5일; 우수포스터상(이창호, 김지현, 한승렬 이성욱)
11th Annual Meeting of Korean Society of Gene and Cell Therapy
Improvement of anti-viral effectiveness through optimization of RNA aptamer against the hepatitis C virus NS5B protein

2017년 11월 4일; 우수포스터상(김지현, 이창호, 이성욱)
12th Annual Meeting of Korean Society of Gene and Cell Therapy
Down-regulation of exosomal miRNAs represses HCV-induced liver fibrosis through deactivation of hepatic stellate cells